The establishment of pilot Free Trade Zones is one of the important measures for China to stimulate regional economic growth through deepening reform and opening up. In this paper, the panel data of 21 cities in Guangdong Province from January 2010 to December 2020 are taken as samples, and the fixed effect model is used to analyze the spillover effect of the Guangdong pilot Free Trade Zone on regional economic growth. The results show that the spillover effect of the Guangdong pilot Free Trade Zone on regional economic growth is significant, with the largest spillover effect on the home city, followed by the Pearl River Delta, which ranks third in Guangdong Province.