Narrow Results

Inspired by the flimmer hairs found on the flagella of certain species of choanoflagellates, we show in this paper that nanoscale flagella hair on slender flagellum surfaces can drive flow with nanoscale motion. Using molecular dynamics, we provide numerical proof that the nanoscale hairs, moving in a biased periodic motion, can attain high water flow rates in excess of 1200 $\mu$m${}^3\cdot$ s${}^{-1}$. This flow rate is on par with the experimentally measured flow rates of natural sponges, which are known to be capable of exceptionally high pumping efficiency. This paper highlights the potential of using collective motion of nanohairs to pump fluid and suggests a range of parameters of the force function that can achieve significant flow.

Flagellin is a main protein present in the bacterial flagellum and its molecular mass is around 51.5 kDa. Its role as an adjuvant vaccine has been intensively studied and currently there is evidence to be an immunomodulador in situations of autoimmune diseases, co-administered with chemotherapy or as radioprotetor. This study focus on to establish the native flagellin production by Salmonella Typhimurium in shake flask and flagellin purification strategy by using tangencial ultrafiltration. Results showed that flagellin can be released to the supernatant depend on the agitation speed, and tangencial ultrafiltration can be used as tool to purify this protein.