Our chapter evaluates the impact of invasive plant species (IPS) on ensuring human food, food security, and food safety. From a survey of 80 IPS, about 58 are directly involved in human food and nutrition. Identified species are categorised into grains (8), vegetables (27), fruits (10), oil (2), and food additives (11); flour and beverages can be complementary sources of human food, providing sufficient nutrients, antioxidants, and phytochemicals for human health. An IPS contains 30 g of carbohydrates, 11 g of protein, 2.1 g of fat, 0.12 g of vitamins, and 0.93 g of minerals. Meanwhile, everyday food consists of 35.43, 11.57, 15.14, 0.15, and 1.07 g of carbohydrates, protein, fat, vitamins, and minerals, respectively. About 100 g of rice contains 78.24 g of carbohydrates, 7.94 g of proteins, 0.25 g of fat, 0.01 g of vitamins, and 0.13 g of minerals. In contrast, 100 g of Kodo millet contains 66.19, 8.92, 2.55, 0.04, and 0.25 g, respectively. This chapters explores a range of beneficial uses for IPS, for instance IPS can indirectly benefit human by improving soil health through manuring, composting, biormediation and erosion control, and they can also act as pollutant purifiers in soil and water. Additionally, IPS can act as indirect sources of protein for humans by providing quality fodder to domestic animals. Multiple utilisation techniques are explored which are more sustainable, affordable, and environmentally friendly measures to control IPS than conventional control measures. Diversified sectors can sustainably manage resources through contributions to medicine, food, fuel, energy, and community participation. It is also revealing that IPS use depends on the social perspectives of different countries or regions. These measures will ensure sufficient safe and nutritious food, increase social safety to outweigh its negative effects, and thus achieve 11 Sustainable Development Goals (SDGs).