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Anti-oxidant refers to such a kind of endogenous or exogenous compound that is able to retard or even prohibit in vivo or in vitro oxidation with only small amount being used. The study of anti-oxidants starts nearly 30 years ago, and the research on this topic in China almost begins simultaneously with that in the world. Gratifyingly, contributions on anti-oxidants from China researchers have rapidly increased in the recent decade as anti-oxidants have become a hot topic in biochemistry, pharmacology, food science, chemistry as well as other related disciplines. Anti-oxidants provide a specific viewpoint for clarifying pharmacological effects of Chinese medicinal herbs. For example, as a traditional Chinese medicinal herb, Panax ginseng C. A. Meyer is found to be a natural anti-oxidant resource. Meanwhile, some signaling pathways such as nuclear factor-κB (NF-κB), nuclear factor erythroid 2 related factor 2 (Nrf2), and Kelch-like ECH associated protein 1 (Keap1) are regarded to play an important role in anti-oxidant responses. These findings provide a substantial basis for understanding the pharmacological behaviors of Chinese medicinal herbs in view of regulating the aforementioned signaling pathways. Moreover, inhibition of reactive oxygen species (ROS) by supplementation of anti-oxidant becomes a popularly accepted idea in keeping health and treating diseases. Isolations of antio-xidative ingredients from medicinal herbs and foods lead to set up a large range of anti-oxidative compound libraries, and intake of anti-oxidants from foods may be the most efficient way for supplementing exogenous anti-oxidants. On the other hand, designing anti-oxidants with novel structures motivates organic and medicinal chemists to explore the structure–activity relationship, and then, to find novel structural features with anti-oxidative properties. Therefore, it is reasonable to believe that China researchers will donate more endeavors to obtain more achievements on anti-oxidants in the future.
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For the month of July 2020, APBN will explore implications the COVID-19 outbreak will have on food security in the Asia Pacific Region. In the Columns dive into primary care in the healthcare system looking at the importance of networks and increasing productivity through digitization. Read more on the interview with Associate Professor Jeremy Lim, founder of Southeast Asia's first stool bank, AMILI as the team works towards generating an understanding of the Asian gut microbiome.
For the month of June 2020, in our Features section, we have an article contribution by Dr Jonathan Teh a Consultant Radiation Oncologist at Asian Alliance Radiation & Oncology (AARO) on how SBRT can provide hope for inoperable kidney cancer. Also in the Features section, we commemorate World Health Day with Viatris.
In the Columns section, look at how the microbiome can be a gateway to wellness in an article contribution by Daniel Ramón Vidal, Vice President of R&D Health & Wellness at ADM. Also, explore how artificial intelligence and advanced analytics can help in enhancing clinical trial process.
In the Spotlights section, we interviewed Jeong Jae Youn, Country Manager for GE Healthcare Singapore & Emerging ASEAN to dive into mammograms and ultrasound methods used for early detection of signs of breast cancer.