Narrow Results

H2 receptor antagonist (H2RA) and proton pump inhibitor(PPI) are often used to treat gastric ulcers, in addition to the zinc-L-carcino-complex which is commonly adopted for such therapies. However, there have been no previous reports detailing the levels and distribution of zinc in human gastric mucosa. The aim of our current study is to clarify the relationship between Helicobacter pylori infection and trace elements such as zinc in gastric mucosa using particle induced X-ray emission (PIXE). Forty gastric ulcer patients were chosen as subjects of this study and divided into two groups. One is a new ulcer patients group(twenty nine cases). And the other, eleven of these patients had been prescribed zinc-L-carcino-complex (polapreZinc^®), at a dose of 150mg/day for periods ranging from 16 to 20 weeks. The zinc levels in the gastric ulcer group were found to be significantly less than those of the control group and the concentrations of zinc in gastric mucosa were observed to increase following the administration of treatments containing this element.

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Gastric mucosa lesions are typical exosyndrome of gastropathy including edema, erosion, bleeding, necrosis, ulcer etc. To detect the characterization of various gastric mucosa lesions, an optical coherence tomography (OCT) system, which can obtain high resolution cross-sectional images of tissue, was used for the detection of microstructure of gastric mucosa lesions in rats. The gastric mucosa lesions animal models were induced in Sprague-Dawley rats by different methods including indometacin, alcohol and acetic acid. These results showed that there were different forms of gastric mucosa lesions in the induced animal model, pathological changes of gastric mucosa can be clearly observed, and the character of the gastric mucosa lesions can be identified by analysis of OCT imaging in a noninvasive and quick way. Our results indicated that OCT can be used to clearly detect the microstructure of gastric mucosa lesion tissue. Thus, the OCT technology, with an ancillary endoscope, maybe be benefit and helpful as a tool to provide an objective diagnostic method for study on gastric mucosa lesions in the clinical practice.