Narrow Results

Australia — Sydney Researchers Unveil the Structure of Cancer Enzyme.

Australia — Australian University Aids in the Establishment of a Biotech Center in Vietnam.

Australia — Australian Researchers Work on Biofuel.

Australia — Queensland's New Wesley Research Institute Tissue Bank for Cancer Tissue Collection.

Australia — LCT Successful in Transplanting Pig Cells in Humans for Insulin Production.

China — China Establishes Medical Insurance Research Institute.

China — AstraZeneca Sets Up Research Base in Shanghai.

China — Industrial Biotechnology Research Center Newly Opened at the Shanghai Institutes for Biological Sciences.

China — China Science Association Publishes Moral Code for Academics.

China — China's Health Ministry to Cooperate with Merieux Alliance for TB Prevention.

China — China to Tighten Supervision of Albumin Medicine.

China — Research Center Set Up for a New Approach to TCM Research.

China — Chinese Scientist Announces Breakthrough in Cancer Research.

Indonesia — Indonesia to Support WHO in Influenza Prophylaxis.

Indonesia — Indonesian Agency for Agricultural Research and Development Collaborates with Philippines-Based IRRI.

Indonesia — Indonesian President Calls to Distribute Bird Flu Vaccines Equally.

India — JIVAS Launches 'Project Padasamrakshane' with Funding from World Diabetes Foundation.

India — CIMAP to Tie Up with Pharmexcil for Promotion of Herbal Plants.

India — Central Drugs Research Institute Develops Three New Anti-diabetic Molecules.

India — Indian Government to Invest in Nanotech.

India — Wyeth to Relocate Operations from China to India.

India — Prices of Generic Medicine to Drop in India.

India — ORBIS Plans 30 Eye Centers in India.

India — Indian Researchers Discovers New Genetic Markers for Coronary Heart Disease.

Japan — Flu Virus Mutants Resist Two Popular Drugs.

Singapore — Therapeutic Antibodies Likely to be Used to Prevent Infectious Diseases.

Singapore — Singapore Stem Cell Bank Ready for Business.

Singapore — Asia Generic Medicines Congress in Singapore Celebrates the Rise of Asian Generics.

Singapore — Singapore and Cambodia Sign Health Pact.

Singapore — New Leadership Appointments at A*STAR's Biomedical Research Council.

South Korea — South Korea to Ban Use of Tamiflu by Teenagers.

INDIA – South Asia waters harbor drug-resistant bugs.

JAPAN – Daiichi Sankyo initiates phase 3 ENSURE-AF study, investigating patients with atrial fibrillation undergoing cardioversion.

SINGAPORE – Scientists discover a number of novel genetic defects which cause esophageal cancer.

SINGAPORE – NUS researchers develop world's first fluorescent sensor to detect common illicit date rape drug.

SINGAPORE – Genome Institute of Singapore partners Nutricia Research to investigate human gut microbiome.

SINGAPORE – Singapore-developed drug coated balloon enrolls its first patients in clinical study.

THE PHILIPPINES – Biodiversity loss linked to outbreaks of diseases.

VIETNAM – Mosquito genes could be key to halting dengue spread.

EUROPE – Curetis obtains key patent for Unyvero™ technology.

NEPAL – Fly ash waste used as water purifier.

UNITED STATES – Researchers discover genetic markers that may predict when people with heart disease are likely to have heart attacks.

UNITED STATES – Celluar ‘counting’ of rhythmic signals synchronizes changes in cell fate.

UNITED STATES – Potential lung cancer vaccine shows renewed promise.

UNITED STATES – Shrink wrap used to enhance detection of infectious disease biomarkers.

UNITED STATES – Triple negative breast cancer's progression and relapse pinned to a gene.

UNITED STATES – Seaweed forests could help power tropical islands.

AUSTRALIA – Potential of Anisina to become major new chemotherapy.

AUSTRALIA – Phylogica peptide fusion kills aggressive breast cancer cells.

INDIA – South Asia running out of groundwater.

JAPAN – Fruit fly studies shed light on adaptability.

KOREA – Hanmi Pharm begins phase 2 clinical trials on new long-acting human growth hormone drug.

MALAYSIA – Researchers discover breakthrough treatment for depression.

MALAYSIA – New diagnosis tool pushed to cope with diabetes in Asia.

SINGAPORE – Scientists discover gene that allows a peek into the future on eye disease.

SINGAPORE – Babies from moms with hepatitis have better immune systems.

THE PHILIPPINES – Debate persists on pneumonia vaccine in the Philippines.

VIETNAM – Second hookworm genome hoped to lead to vaccines.

AFRICA – Shop-based malaria kit boosts testing for disease.

BRAZIL – Prospective Chagas vaccine proves effective in trials.

EUROPE – Vaccine against placental malaria to start human tests in Germany and Benin.

SRI LANKA – Sri Lankan farmers told to adapt to changing climate.

UNITED STATES – Genetic markers play a role in who benefits from aspirin, NSAIDs to lower colon cancer risk.

UNITED STATES – Potential Ebola treatment mechanism discovered.

UNITED STATES – Researchers develop new potential drug for rare leukemia.

UNITED STATES – Researchers find new link between neurodegenerative diseases and abnormal immune responses.

Papillary thyroid carcinoma (PTC) is typically an indolent cancer, yet a minority of cases develop lymph node metastasis. Due to the unclear mechanisms of lymph node metastasis, a considerable number of patients undergo unnecessary surgeries. Currently, the identification of key genetic biomarkers in high-dimensional data presents a significant challenge, thereby limiting research progress in this area. Here, we proposed a hybrid filter-wrapper feature selection strategy for core factor detection and developed MethyAE, a metastasis prediction model based on DNA methylation, utilizing an end-to-end learning auto-encoder. 46 methylated CpG sites were successfully identified as crucial biomarkers for lymph node metastasis. Leveraging 447 PTC samples from the Cancer Genome Atlas (221 with metastasis, 226 without), the MethyAE model achieves 88.9% accuracy and a recall rate of 88.6% in predicting lymph node metastasis, outperforming commonly used machine learning methods like logistic regression and random forest. Furthermore, the MethyAE model exhibits favorable performance in DNA methylation data from colon cancer, bladder cancer, and breast cancer. To the best of our knowledge, this is the first attempt to predict PTC lymph node metastasis through DNA methylation, offering pivotal decision-making criteria for avoiding unnecessary surgeries and selecting appropriate treatment plans for a substantial cohort of PTC patients.