Narrow Results

The effects of chronic treatment with hot water extract of Bitter Melon (Momordica charantia L.) or Ginger Rhizome (Zingiber offifinale Rosc) on spontaneous mammary tumorigenesis were examined in SHN virgin mice. In mice given free access to extract of Bitter Melon (0.5%) or Ginger (0.125%) in drinking water, the development of mammary tumors was significantly inhibited. Furthermore, the former inhibited uterine adenomyosis with a common pathological background to mammary tumors and the latter inhibited mammary tumor growth. While the mechanism of the effects of these natural products remains to be clarified, there were no adverse effects of chronic treatment with these agents as estimated from body weight, food and water intake and various plasma component levels as well as external appearance. Thus, these natural products, popular in Japan as foodstuffs, also appear to have a health benefit.

Hepatic fibrosis is an over-accumulation of extracellular matrix (ECM). It is a result of an imbalance between collagen synthesis and degradation. Matrix metalloproteinase (MMP) has degradative activity against collagen, but tissue inhibitors of metalloproteinase (TIMP) control the active forms of MMP by blocking the active site of MMP. In our study, we established the bile duct ligated model (BDL) in rats to evaluate anti-fibrotic potential of Chinese medicine sho-saiko-to (TJ-9). We assessed the drug's potential in inhibiting collagen accumulation, suppressing procollagen α1 types (I) and (III), and TIMP-1 mRNA expression. After administration of TJ-9, hyperbilirubinemia reduced approximately four-fold when compared with BDL-untreated group. TJ-9 also significantly reduced the collagen content and fibrogenic score, as well as downregulated elevated procollagen α1 types (I) and (III) and TIMP-1 mRNA level. Finally, we concluded that (1) TJ-9 significantly reduced cholestasis in rats with BDL, (2) TJ-9 markedly reduced the collagen content by 50%, and (3) TJ-9 exerted its antifibrogenic effect by downregulation of the mRNA expression of procollagen α1 types (I) and (III), and TIMP-1 in liver tissue.

In this study, we evaluated the synergistic effect of ginger and nifedipine on anti-platelet aggregation in normal human volunteers and hypertensive patients. The results showed that the percentage of platelet aggregation induced by collagen, ADP and epinephrine in hypertensive patients was larger than that in normal volunteers. Either aspirin or ginger could potentiate the anti-platelet aggregation effect of nifedipine in normal volunteer and hypertensive patients. These results suggested that ginger and nifedipine possessed synergistic effect on anti-platelet aggregation. A combination of 1 g ginger with 10 mg nifedipine per day could be valuable for cardiovascular and cerebrovascular complication due to platelet aggregation.

The natural product ginger (Zingiber officinale) has active constituents gingerol, Shogaol and Zerumbone, while turmeric (Curcuma longa) contains three active major curcuminoids, namely, curcumin, demethoxycurcumin, and bisdemethoxycurcumin. They have the same scientific classification and are reported to have anti-inflammatory and many therapeutic effects. This article reviews the physiological and therapeutic effects of ginger and turmeric on some endocrine gland functions, and signal pathways involved to mediate their actions. With some systems and adipose tissue, ginger and turmeric exert their actions through some/all of the following signals or molecular mechanisms: (1) through reduction of high levels of some hormones (as: T4, leptin) or interaction with hormone receptors; (2) by inhibition of cytokines/adipokine expression; (3) acting as a potent inhibitor of reactive oxygen species (ROS)-generating enzymes, which play an essential role between inflammation and progression of diseases; (4) mediation of their effects through the inhibition of signaling transcription factors; and/or (5) decrease the proliferative potent by down-regulation of antiapoptotic genes, which may suppress tumor promotion by blocking signal transduction pathways in the target cells. These multiple mechanisms of protection against inflammation and oxidative damage make ginger and curcumin particularly promising natural agents in fighting the ravages of aging and degenerative diseases, and need to be paid more attention by studies.

Ginger is a commonly used spice and herbal medicine worldwide. Besides its extensive use as a condiment, ginger has been used in traditional Chinese medicine for the management of various medical conditions. In recent years, ginger has received wide attention due to its observed antiemetic and anticancer activities. This paper reviews the potential role of ginger and its active constituents in cancer chemoprevention. The phytochemistry, bioactivity, and molecular targets of ginger constituents, especially 6-shogaol, are discussed. The content of 6-shogaol is very low in fresh ginger, but significantly higher after steaming. With reported anti-cancer activities, 6-shogaol can be served as a lead compound for new drug discovery. The lead compound derivative synthesis, bioactivity evaluation, and computational docking provide a promising opportunity to identify novel anticancer compounds originating from ginger.

China-Germany sci-tech cooperation continue to bring more opportunities.

Study reveals mechanism behind ginger’s warming effect on body.

Doctors in Guangzhou conduct 5G-assisted remote ultrasound scan.

China proposes major changes to pharmaceutical regulations.

Hangzhou attracts RMB1.5 billion investments in bio-pharmaceutical projects.

Genetic testing encouraged to prevent ovarian cancer.

New technology enables large-scale production of artemisinin for malaria.

Shanghai wants to develop top health innovation zone.

New synthetic biology research center launched in Shanghai.

Chinese scientists suggest new thoughts in lupus treatment.

Introduction: An important worldwide health concern that has an adverse effect on both people and societies is obesity. It may result in diseases linked to obesity, a lower standard of living, or even death. Therefore, there is a pressing need for more advanced and novel drug delivery techniques, such as topical therapy, to treat obesity. However, there are several obstacles to overcome, including low molecular weight, high lipophilicity, limited efficacy, and skin irritation. It seems that nanoliposomes (NLPs) are a nearly ideal drug-carrier system. They are thought to be the best delivery vehicles for physiologically active substances, both in vitro and in vivo, due to their advantages in biology and technology. Material and Method: Carboxy methyl cellulose-based gel containing NLPs loaded with chilli pepper and ginger extracts (CMC-gel containing Chi/G-NLPs) has been studied. The NLPs containing the extracts are synthesized using a thin layer hydration and ultrasound method. Then nanocarrier’s physicochemical properties, drug loading capacity, and rate of release are evaluated. Results: Scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR), dynamic light scattering (DLS), Zeta potential (ZP), in vitro release profile, and in vitro skin absorption assays verify the optimal physicochemical characteristics, 30% in vitro skin absorption and slow control in vitro release behavior. Conclusion: When considered collectively, our findings supported the idea that using Chi/G-NLPs in a CMC-gel will optimize its effectiveness as an innovative topical therapy for obesity.

Now growing at a rate of over 5% per annum, the $3 billion ‘alternative health therapies’ business is now positioned in the top ten growth industries in Australia. With poor regulation of both therapeutic goods and the unregistered therapists who promote them, cancer patients may well be putting their health at risk when they place their faith in many so-called ‘natural’ or ‘traditional’ treatments. With a focus on what complementary therapists refer to as ‘energy medicine’ and ‘nutritional medicine’, this chapter explores the risks and benefits of some of the more popular alternative health-care choices. While investigating their histories, it outlines what influences cancer patients to try these unproven therapies, and the conflict and contrast in information relating to the claims made for them and the conclusions of evidence-based research. Although there are a number of complementary therapies that are of benefit to some patients, both during and after their cancer treatments, ‘natural’ does not always equal ‘safe’, may be expensive and may even compromise their health. More patients now want a greater say in their choices of treatment, and selecting complementary therapies that may help is another of the many challenges faced in trying to make informed choices, as we navigate along our individual roads on our journeys to recovery.