Narrow Results

During these last years, the substantially biological field effect transistors (BioFET) are one of the most abundant classes of electronic sensors for biomolecular detection. The determination of glucose levels using these biosensors, especially in the medical diagnosis and food industries, is gaining popularity. Among them, ion-sensitive field effect transistor (ISFET) is considered one of the most intriguing approaches in electrical biosensitivity technology. The glucose sensor ISFET detects the glucose molecule by catalyzing glucose to gluconic acid and hydrogen peroxide in the presence of oxygen. In this paper, first of all we examine some of the main advantages in this field, the perspective of applications and the main issues in order to stimulate a broader interest in the development of biosensors based on ISFET and to extend their applications for a reliable and sensitive glucose analysis. Thereafter, a biosensor with field effect sensitive to the ions for the detection of glucose is modeled analytically. In the proposed model, the glucose concentration is presented according to the gate voltage. The simulated data show that the analytical model can be used with an electrochemical glucose sensor to predict mechanism’s behavior of detection in the biosensors.

In this paper, we first fabricated a nanoPt modified platinum electrode. Then through a simple method, the electrode surface was introduced with a submonolayer of bismuth that acted as an effective promoter. Cyclic voltammetry and other characterizations were employed. The obtained Bi^III/nanoPt/Pt electrode exhibited two greatly increased oxidation peaks at negative and positive potential areas, respectively. The signals were far larger than that of platinum electrode because of the large true surface area of nanoparticles and the catalysis of bismuth adsorbed on platinum. In the presence of bismuth, the platinum active sites could combine with more OH^- from bismuth hydroxyl to form a new active site for the oxidation of glucose. The prepared Bi^III/nanoPt/Pt electrode given high sensitivity and excellent linearship to glucose detection and showed the potential application in the areas of electrocatalysis or electroanalysis.

In this work, we electrochemically developed a palladium–polypyrrole composite film on a silicon semiconductor support, and then studied its electrocatalytic activity — as an anode — towards the oxidation of glucose in an alkaline medium. The obtained electrode is characterized by various physicochemical techniques such as scanning electron microscopy (SEM), atomic force microscopy (AFM) and X-ray fluorescence (XRF). The results show that the presence of the polymer film on the Si support improves the conductivity of the latter and that the presence of palladium on the polymer film is at the origin of the reactivity of the electrode for glucose oxidation.

This work presents the preparation of a gold-polypyrrole (Au-PPy) composite film on a silicon (Si) semiconductor supported by electrodeposition, and the study of its electrocatalytic activity as an anode catalyst for the glucose oxidation reaction in alkaline media. The microstructure of the as-prepared Au-PPy film is characterized by scanning electron microscopy (SEM) and atomic force microscopy (AFM). The results show that the presence of the polymer film on the Si support improves the conductivity of the latter and enables better distribution of the Au microparticles on the electrode surface, thus helping to increase their catalytic activity for glucose oxidation.

Exploring the Role of Glutathione in the Regulation of Immune Cell Function.

Does Oxidative Damage Cause Poor Healing?

Pathogenesis of Atopic Dermatitis in Singapore.

Proteomics and Colorectal Cancer Metastasis: Bird's-Eye View on Current Scenario and Our Contribution.

Zebrafish: A Small Fish Model for a Big Human Disease.

The Reign of a New Dictator: Circulating MicroRNA in Diabetes.

Engineering Artificial Vascularized Bone Grafts for the Repair of Large Bone Defects.

A 'Nano' Era for Blood Glucose Sensing.

Ancient Medicine with Newer Roles: Potential Role of Celastrol in the Treatment of Multiple Myeloma.

Proteins, Proteome and Proteomics.

A Novel Promising Biomarker and Therapy Target of Liver Cancer.

Understanding Diabetes

Prediabetes: The Gap between the Onset of Disease and Initiation of Treatment.

Diabetes: A Dietitian’s Perspective.

Use of Modelling for Better Diabetes Care.

No More Highs and Lows with Toujeo®: A New and Improved Insulin Injection.

Glucose-, galactose- and lactose-containing photosensitizers based on derivatives of chlorophyll a and bacteriochlorophyll a were synthesized with the use of [3+2] cycloaddition between sugar azides and triple bond derivatives of chlorins and bacteriochlorins. Unlike bacteriochlorin cycloimide, chlorin was detected to form a Cu-complex during the click reaction. An approach to the synthesis of metal-free glycosylated chlorins was developed with the use of "protection" by Zn²⁺ cation and subsequent demetalation. It is based on the action of alkynyl chlorin e₆ derivative Zn-complex, which is resistant to the substitution by copper cation. Bacteriochlorin p cycloimide conjugate with per-acetylated β-D-lactose was obtained and shown to become water-soluble after unblocking of the lactose hydroxy functions. NMR studies allowed for the elucidation of structure, tautomeric form and conformation of the obtained compounds.

This review summarizes the applications of metallophthalocyanine (MPc) and metallo-porphyrin (MP) complexes as electrocatalysts immobilized onto various electrodes for the detection of hydrogen peroxide and glucose. The uses of MPc and MP complexes as electron mediators for the detection of glucose at glucose oxidase modified surfaces are discussed.

The synthesis of derivatives bearing glucose or galactose units linked by an acrylate spacer to one free meso position of a bis-aryl-porphyrin macrocycle was developed and characterized by standard spectroscopic techniques. The new mono-substituted gluco- and galacto-porphyrin derivatives 5–8 present an alternative to the widespread tetra-aryl porphyrin functionalization. Singlet oxygen studies showed a comparable singlet oxygen production with TPP. Furthermore, the less bulky architectures here synthesized present an opportunity to enhance the PDT and PDI capabilities of glycoporphyrins with a simple synthetic modification at one of the meso positions.

The development of peroxidase mimics with enhanced peroxidase-like activity is critical to building a convenient and fast glucose colorimetric sensor. Herein, a porphyrin-based conjugated microporous polymer (FePCMP) was synthesized through a Pd-/CuI catalyzed Sonogashira coupling reaction. The FePCMP exhibited specific and superior POD-like activity evaluated by the fast oxidation of 3,3$\prime$,5,5$\prime$-tetramethylbenzidine (a chromogenic substrate, TMB) to form the blue product (oxTMB) in the presence of H₂O₂. The outstanding POD-like activity is mainly ascribed to the Fe-N₄ active sites and the cross-linked porous framework of FePCMP. Furthermore, the FePCMP was applied in selective colorimetric detection of glucose through a glucose oxidase biocatalytic cascade reaction with a low detection limit (LOD) of 0.031 $\mu$M in the linear range of 0.2–5 $\mu$M. This study not only provided a new method for the design and synesis of specific POD-like nanozymes, but also the prepared FePCMP can be used as a POD-like enzyme for the colorimetric detection of other molecules, such as cholesterol, acetylcholine, etc.

In order to develop non-noble metal-based electrocatalysts for glucose oxidation, the Ni-doped, urchin-like Bi₂S₃ particles were prepared by a solvothermal method using the solvent of ethylene glycol/H₂O. The obtained products were characterized by scanning electron microscopy, transmission electron microscopy, X-ray photoelectron spectroscopy and X-ray diffraction. The background signal from capacitance current is relatively low and the electrocatalytic oxidation current of glucose relatively high due to the urchin-like nanostructure of Bi₂S₃ particles and high surface area where the presence of Bi also improves the electrocatalytic performance of Ni${}^{II}$/Ni${}^{III}$ shift.

The sun is the only source of renewable energy available to us, if geothermal energy is not taken into account. In the form of radiation (UV light, visible light, infrared light, Section 1.1) it sends us annually 178,000 terawatts (1 TW = 10¹² W; unit of power 1 W = 1 J s^–1 = 859.85 calories per hour), that is to say 15,000 times the energy consumed annually by humanity. Only 0.1% of the solar energy received by planet Earth is converted into plant biomass, i.e. 100 × 10⁹ tons per year which corresponds to ca. 180 × 10⁹ tons per year of CO₂ captured from the atmosphere. This CO₂ returns to the biosphere after the death of the plants. Consumption of fossil carbon emits ca. 35 × 10⁹ tons of CO₂ yearly. Biomass is the material produced by all living organisms (plants, animals, microorganisms, fungi)…