For coprime integers p(>0)p(>0) and qq, the (p,q)(p,q)-cable ΓΓ-polynomial of a knot is the ΓΓ-polynomial of the (p,q)(p,q)-cable knot of the knot, where the ΓΓ-polynomial is the common zeroth coefficient polynomial of the HOMFLYPT and Kauffman polynomials. In this paper, we show that there exist infinitely many knots with the trivial (2,1)(2,1)-cable ΓΓ-polynomial, that is, the (2,1)(2,1)-cable ΓΓ-polynomial of the trivial knot. Moreover, we see that the knots have the trivial ΓΓ-polynomial, the trivial first coefficient HOMFLYPT and Kauffman polynomials.