We investigate the well-posedness in the generalized Hartree equation iut+Δu+(|x|−(N−γ)∗|u|p)|u|p−2u=0, x∈ℝN, 0<γ<N, for low powers of nonlinearity, p<2. We establish the local well-posedness for a class of data in weighted Sobolev spaces, following ideas of Cazenave and Naumkin, Local existence, global existence, and scattering for the nonlinear Schrödinger equation, Comm. Contemp. Math. 19(2) (2017) 1650038. This crucially relies on the boundedness of the Riesz transform in weighted Lebesgue spaces. As a consequence, we obtain a class of data that exists globally, moreover, scatters in positive time. Furthermore, in the focusing case in the L2-supercritical setting we obtain a subset of locally well-posed data with positive energy, which blows up in finite time.