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Clinical results of photodynamic therapy continue to show promise for the treatment of various solid malignancies. This paper briefly summarizes the advantages/disadvantages of various so-called ‘second-generation’ photosensitizers and other medical applications of porphyrin-based analogs.
Photodynamic therapy is a method for treating several diseases, most notably cancer. Recent synthetic activity has created a number of phthalocyanines for potential use as photodynamic therapy photosensitizers. In this mini-review article, the background and the concepts in the development of new phthalocyanines are introduced.