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A novel coplanar waveguide (CPW) fed circular slot antennas are proposed for industrial, scientific and medical (ISM) band (2.4–2.48 GHz) applications. To make the designed antenna suitable for implantation, it is embedded in biocompatible Al2O3 ceramic substrate. The antenna was simulated by immersing it in a phantom liquid, imitating the electrical properties of the human muscle tissue. A study of the sensitivity of the antenna performance as a function of the dielectric parameters of the environment in which it is immersed was performed. Simulations in various dimensions state demonstrate that the antenna covers the complete ISM band. The demonstration among the design EM characteristics of the antenna is presented by current distributions.