Narrow Results

This paper presents a new SIRI propagation model based on SIR model. Behavioral motivation value and neighbor infection number influence value were added to the model to study the effects of these two quantities on behavior transmission. In order to make the model closer to the real situation, self-motivation value and neighbor influence value are added to the behavior motivation value. Compared with previous studies, our proposed experimental model is closer to the real world, improves the possibility of behavior prediction, and is validated by simulation. Finally, this paper takes Lanzhou Polytechnic University campus cartoon consumption data as an example to test and validate the model.

We develop simple models for the global spread of infectious diseases, emphasizing human mobility via air travel and the variation of public health infrastructure from region to region. We derive formulas relating the total and peak number of infections in two countries to the rate of travel between them and their respective epidemiological parameters.

Two different theoretical functions are proposed for the age-dependent transmission coefficients which takes into account the distribuitions of the contact probabilities between susceptible individuals of age a with infected individuals of age a′. A numerical simulation is presented with measles and rubella data from two distinct communities. The impact of control measures is also simulated using the assumed functions for the age-dependent transmission coefficients.

Purpose: Minimally invasive plate osteosynthesis (MIPO) is used for the treatment of distal tibial fractures, especially in cases of intra-articular fractures. There are many advantages of MIPO, including preservation of blood supply to the fracture site and enhanced bone healing, however, it is not without complication. The study aimed to elaborate the benefits of MIPO technique in managing distal tibia fractures and to describe the necessities for good union and functional outcome. Methods: A total of 38 patients with distal tibia comminuted and spiral fractures, having closed distal tibia AO/OTA 43-A, B or C fractures with or without fibular fractures, were included. All the cases were assessed for union time, complications and functional outcomes. Binomial regression using $R$ v3.6.0 was used to assess the success of MIPO based on four-cortex alignment. $P$ value $<0.05$ was considered statistically significant. Results: The mean operative time was 70min. All 38 tibial fractures united and the mean union time was found to be 18 weeks. Five cases were noted to have complications (four superficial infections and one implant failure). Out of 38 patients, 28 (majority) showed excellent functional outcomes as assessed by the American Orthopaedic Foot and Ankle Society score, i.e. a score of $\ge$90. Conclusion: MIPO is a good method for the management of tibial fractures with extra-articular and intra-articular involvement, with good union even when absolute four cortical contact is not achieved.

Bharat Biotech Patents Unique Molecule To Treat Infections.

AUSTRALIA – First iPS Cell Line Puts Australia in the Lead of Stem Cell Research.

AUSTRALIA – New Treatment Hope for Prostate Cancer.

CHINA – AIDS Is China's Top Killer Among Infectious Diseases.

CHINA – Anti-bird Flu Drug for Human Clinical Trial Approved by China.

CHINA – China Plans 120 Billion Dollar Health Reform By 2011.

CHINA – 13 000 Fowl Culled in China After Bird flu.

CHINA – China-Russia Joint Research Center.

CHINA – Pig's Adult Stem Cells Produce Better Skins.

CHINA – More Health Scares Amid Slowdown, Warns China.

INDIA – Indian Experts Find Bacteria to Beat Global Heat.

INDIA – Two Indian Firms to set up Pre-clinical Trial Units in Malaysia.

JAPAN – Breakthrough in Universal Flu Vaccine Development.

SINGAPORE – Taiwan Pork Banned by AVA.

SINGAPORE – Stem-Cell Treatment For Joint Pain Gives New Hope.

SINGAPORE – Next Generation Healthcare Information System.

SINGAPORE – Top US University Sets up Research Centre in Singapore.

SINGAPORE – Increase in Life-saving Umbilical Cord Donations.

SINGAPORE – Singapore and China Scientists Report Breakthrough Research in Psoriasis.

SOUTH KOREA – Harmful Bacteria in French Baby Formula.

SOUTH KOREA – World's First Cloned Wolves to Test Reproductive Fitness.

TAIWAN – Genetic Testing on the Rise.

TAIWAN – Chinese Herbal Medicines Contain Western Drug Ingredients.

VIETNAM – Bird Flu Strikes in Five Provinces in Vietnam.

VIETNAM – Opening of Vietnam's First Stem Cell Bank, "MekoStem".

VIETNAM – Hanoi Suffers Worst Measles Outbreak in Decade.

OTHER REGIONS — EUROPE – Social Networking = Disease?

OTHER REGIONS — EUROPE – Cancer Morbidity 'to Double in 40 Years'.

OTHER REGIONS — NORTH AMERICA – Scientists Close in on 'Universal' Vaccine for Flu.

OTHER REGIONS — NORTH AMERICA – Hong Kong and US Scientists Develop New Bird Flu Vaccine.

AUSTRALIA – Australia Developing Breakthrough Leukemia Research Strategy.

AUSTRALIA – Obesity Associated With Detrimental Changes in Ovary.

AUSTRALIA – Queensland's Dengue Outbreak Worsens.

CHINA – Global Fund Assists Guangxi In Anti-AIDS Programs.

CHINA – Chinese Scientists Clone 5 Human Embryos for Research.

CHINA – China Stockpiles Vaccine for Possible Bird Flu Outbreak.

CHINA – QIAGEN Supports Cervical Cancer Screening for Underprivileged.

CHINA – JCI and Peking University Collaborate on Patient Safety and Education in China.

CHINA – Scientists Identify Key Drug Target in Bird Flu Virus.

CHINA – China Facing Burden from Chronic Diseases.

CHINA – Chinese Scientists Discover Achilles' Heel for SARS Virus.

CHINA – 18 HFMD Child Fatalities in China.

CHINA – Mainland China Reports 838 Infectious Disease Fatalities in February.

HONG KONG – Lethal Fungal Contamination in Drug.

HONG KONG – Hong Kong Experiences Record High HIV Infection Level.

INDIA – Stem Cells Help Save Man's Leg From Amputation.

INDIA – Human Trials for Kalaazar Vaccine Soon.

INDIA – Stem Cell Banks Expand on Prospects of Healthy Dividend.

INDIA – Biotech Rice to be Commercially Available in India by 2012.

INDIA – Rising Demand for Herbal Medicines in Jammu Kashmir.

INDIA – India, UNESCO to Set up Biotech Centre.

INDONESIA – Health Ministry Clears up Vaccine Dispute.

JAPAN – Bird Flu Detected in Second Quail Farm in Central Japan.

NEW ZEALAND – NZ Med Tech Sector Continues to Thrive.

NEW ZEALAND – Aerobics Classes can Cause Hearing Damage.

SINGAPORE – Dengue fever is on the rise in Singapore.

SINGAPORE – Will New US Policy Stem Talent Flow to Singapore?

SINGAPORE – HBOT Now Available at SGH.

SINGAPORE – Cancer Society's Colorectal Screenings Helped Save 123 lives.

SINGAPORE – National Heart Centre Singapore Unveils New Techniques for Heart Patients.

SINGAPORE – NTU Seals Global Partnerships in Environmental Sciences R&D.

SINGAPORE – NUH Cancer Center in Major Cancer Drug Trial.

SINGAPORE – Need More Trained Doctors? Build New Medical School.

VIETNAM – Harmful Bacteria Found in Bottled Water.

OTHER REGIONS — EUROPE – Hot Tea Linked to Throat Cancer.

USA – New Vaccine Method 'Offers Instant Immunity'.

AUSTRALIA – Immune System Boost Cures HIV-like Infections.

AUSTRALIA – Scientists Shed New Light on How Heart Works.

AUSTRALIA – IVF Breakthrough will Increase Chance of Pregnancy.

AUSTRALIA – Study Reveals Possible Secret to Long Life.

AUSTRALIA – Australian Scientists Make Important Discovery for Safer Drugs.

INDIA – Over 40,000 Childhood Cancer Cases in India Every Year.

INDIA – Biotech Sector Set for Booster Dose.

NEW ZEALAND – Laser to Help Predict Foot Ulcers in Diabetics.

PHILIPPINES – Turning School Yards into Vegetable Gardens.

TAIWAN – Key Enterovirus Breakthrough Unveiled.

OTHER REGIONS — New Heart Therapy More Effective in Women.

A Crisis in the Development of Antibiotics.

Bacterial Culture and Anti-microbial Susceptibility Testing – their Use in Guiding Therapy.

Epidemiology and Impact of Multi-Drug Resistant Gram Negative Infections in Critically Ill Patients in Asia.

Antibiotics and Resistance in Ocular Infections – Indian Perspective.

INDIA – Zinc Treatment for Infections in Children.

JAPAN – Japan Pharma Portfolio Finds Renewed Strength through Record Growth in 2012.

JAPAN – Joint Development of a Novel Lyophilized Dual Chamber Prefillable Syringe System.

JAPAN – A Genetic Alternative to Fertilizer.

SINGAPORE – Made-in-Singapore H5N1 Bird Flu Diagnostic Kit - Detects All Known Strains of H5N1 Virus with a Single Test.

THAILAND – KEEEN, Thai Bioremediation Product, Awarded Gold Medal for "Bioremediation Agent developed to Greenovation Product".

EUROPE – MorphoSys Antibody Reaches Major Milestone in Collaboration with Roche.

EUROPE – New Technique to Predict Heart Attacks.

USA – FEI Launches 'Living Lab' for Structural Biology Research at NIH.

USA – Synthetic Platelets Built to Treat Bleeding.

USA – Software Scans Tongue for Signs of Disease.

USA – US Legislation Will Ensure Tighter Checks on Foreign Drug Factories.

JAPAN – Waseda University team sheds light on self-organization of biological structures.

SINGAPORE – Unravelling the mind-body connection with power-efficient IC chip jointly developed by A*STAR IME, NTU and NUS.

SINGAPORE – A*STAR scientists bring to light mechanism of drug for infections.

SINGAPORE – A*STAR scientists uncover potential drug target to nip cancer in the bud.

THAILAND – Leaders in fight against typhoid express hope in light of new vaccines.

THE PHILIPPINES – GM corn ‘benefits poor more than richer farmers’.

THE PHILIPPINES – Speeding up photosynthesis for better rice yields.

AFRICA – End of line for hard-to-detect malaria?

AUSTRALIA – Drugs to be developed against genetic and degenerative disorders.

AUSTRALIA – A new way to find out if back problems need surgery.

AUSTRALIA – Researchers solve a mystery about type 2 diabetes drug.

EUROPE – Scientists start to tap marine microbes for biotech use.

US – MR spectroscopy shows differences in brains of preterm infants.

US – New device offers hope to people blinded due to incurable eye disorders.

US – New Parkinson's disease genes discovered.

US – Taste receptors in the gut identified as new target for satiety and glucose regulation.

US – ACC inhibitors for potential treatment of diabetes, NASH and liver cancer discovered.

US – Benign tumors from use of oral contraceptive have a greater chance of becoming malignant.

One Step Closer to Predicting Cancer Risk.

China Reveals Plans for National Lab System.

CSA Group Grants Philips Suzhou its First CPC Laboratory Qualification in China.

China-Myanmar Established Biodiversity Research Institute Unveiled in Nay Pyi Taw.

Athenex and Beijing Sciecure Pharmaceutical Announce Binding Agreement to Launch and Market Five Injectable Pharmaceutical Products in North America.

MicuRx Initiates Phase 3 Clinical Trial for MRX-I, A New Potent Oral Antibiotic Against Gram-positive Bacteria, Including MRSA.

WuXi AppTec Receives Inaugural "Company of the Year" Award from BayHelix.

The US FDA Granted Orphan Drug Designation to Yisheng Biopharma's Biological Product for Hepatocellular Carcinoma.

China Promotes Sci-Tech Cooperation Along Belt and Road.

Infinitus launches Joint Laboratory for the Research of Modern Preparation Technology with Huazhong University of Science and Technology.

Asia-Pacific’s Invisible Malaria Problem.

Philips Launches Health Continuum Space to Enable Co-Creation of Future Healthcare Innovations.

Surgical site infection is a common cause of post-operative morbidity, often leading to implant loosening, ultimately requiring revision surgery, increased costs and worse surgical outcomes. Since implant failure starts at the implant surface, creating and controlling the bio-material interface will play a critical role in reducing infection while improving host cell-to-implant interaction. Here, we engineered a biomimetic interface based upon a chimeric peptide that incorporates a titanium binding peptide (TiBP) with an antimicrobial peptide (AMP) into a single molecule to direct binding to the implant surface and deliver an antimicrobial activity against S. mutans and S. epidermidis, two bacteria which are linked with clinical implant infections. To optimize antimicrobial activity, we investigated the design of the spacer domain separating the two functional domains of the chimeric peptide. Lengthening and changing the amino acid composition of the spacer resulted in an improvement of minimum inhibitory concentration by a three-fold against S. mutans. Surfaces coated with the chimeric peptide reduced dramatically the number of bacteria, with up to a nine-fold reduction for S. mutans and a 48-fold reduction for S. epidermidis. Ab initio predictions of antimicrobial activity based on structural features were confirmed. Host cell attachment and viability at the biomimetic interface were also improved compared to the untreated implant surface. Biomimetic interfaces formed with this chimeric peptide offer interminable potential by coupling antimicrobial and improved host cell responses to implantable titanium materials, and this peptide based approach can be extended to various biomaterials surfaces.

Background: Flexor sheath infections require prompt diagnosis, and management with intravenous antibiotics and/or surgical washout followed by hand therapy. Complication rates as high as 38% have been reported. Our unit takes a relatively conservative approach to the management of flexor sheath infections and select patients are managed non-surgically via our outpatient antibiotic service where they are clinically reviewed and receive a once daily dose of intravenous antibiotics. The aim of this study is to determine if outpatient management of flexor sheath infections was associated with an increased risk of complications compared to those admitted as an inpatient.

Methods: A retrospective review was carried out with all patients clinically diagnosed with flexor sheath infection who were seen at our unit between January 2014 and December 2020. Age, gender, co-morbidities, cause of infection, management and subsequent complications were recorded.

Results: A total of 128 patients with flexor sheath infections were treated. And 68% were male. Mean age was 50.4 years. A trend towards fewer presentations each year with animal bites, foreign bodies and penetrating trauma as the main cause of infection was noted. And 89% (n = 114) required admission with the other 11% (n = 14) treated as an outpatient. And 77% (n = 98) underwent surgical washout. And 6% (n = 8) suffered a complication.

Conclusions: While flexor sheath washout continues to be standard practice, 23% of patients were safely managed with intravenous antibiotics and 11% purely via an outpatient service.

Level of Evidence: Level IV (Therapeutic)

Background: Native joint septic arthritis (NJSA) of the hand is poorly studied. Management guidelines are extrapolated from large joint infections despite differences in epidemiology, anatomy and aetiology. Limited evidence suggests shorter courses of antibiotics can achieve outcomes comparable to longer courses. The aim of our study is to characterise the presentation, management and outcomes of NJSA of the hand in an adult cohort from Southeast Queensland (SEQ) and determine if the route or duration of antibiotics affected the outcome. Our cohort was compared to those in the literature to determine if already published data could be applicable to our population.

Methods: A coding based retrospective cohort of adult patients between 2016 and 2022 were assessed. The cohort was divided into short/long course antibiotics and primarily intravenous/oral route for outcome comparison.

Results: Seventy-four patients were included with a joint culture positive rate of 75%. The most common aetiology of infection was direct trauma and the most common pathogen was Staphylococcus aureus. Resolution was achieved in 86% of patients after 1-year follow-up, with a median antibiotic duration of 14 days, and 48% had non-infectious sequelae. Failure to achieve resolution was associated with females and taking immunosuppressants. No significant difference was detected when analysed for primary route or duration of antibiotics.

Conclusions: There was no difference in the rate of resolution attributable to the route or duration of antibiotics. We demonstrated comparability between our cohorts’ demographics, management and outcomes with those in the literature. Based on the findings in our study, noting the retrospective nature and small cohort, the authors conclude for uncomplicated NJSA of the hand, a total antibiotic duration of 14 days in addition to early surgical intervention is likely to be successful in most patients.

Level of Evidence: Level III (Therapeutic)