The generalized hypercube is a highly-connective network proposed by Bhuyan and Agrawal. In this paper, we study the restricted connectivity and fault-free unicast algorithm in the generalized hypercube. Firstly, we prove that the restricted connectivity of a rr-dimensional generalized hypercube G(mr,mr−1,…,m1)G(mr,mr−1,…,m1) is 2κ(G)−n2κ(G)−n, where κ(G)κ(G) denotes the connectivity of G(mr,mr−1,…,m1)G(mr,mr−1,…,m1) and n=n= max {m1,m2,…,mr}{m1,m2,…,mr}, under the condition that each vertex has at least one fault-free neighbor. It is almost twice the traditional connectivity of G(mr,mr−1,…,m1)G(mr,mr−1,…,m1). Furthermore, we present an O(κ(G)3)O(κ(G)3) fault-free unicast algorithm in the generalized hypercube.