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Two novel axially-substituted asymmetric silicon (IV) phthalocyanines, the first one substituted with both polyethylene glycol and indomethacin groups (Pc1) and second one substituted with both polyethylene glycol and mefenamic acid groups (Pc2) have been designed and synthesized for the purpose of pH sensing examinations. Their absorption and fluorescence emission-based spectral properties were investigated in chloroform, tetrahydrofuran and toluene. The pH-sensing properties of Pc1 and Pc2 were examined in detail by using UV-vis absorption and fluorescence spectroscopies in tetrahydrofuran. The effects of the substituents on the spectroscopic properties and pH-sensing behavior of these silicon phthalocyanines were revealed. Pc1 didn’t show a pH response; however, Pc2 exhibited a signal increase from pH 5.40 to 0.37 (turn on) and a drastic quenching when pH went from 0.37 to 5.40 (turn off). The protonation/deprotonation stage of the NH group of Pc2 presented fluorescence-based “on-off” type molecular switch properties.

The interaction between pyropheophorbide methyl ester (PPME) and Cu²⁺ was investigated using UV-vis and fluorescence spectrscopy. Study of the binding interaction between PPME and Cu²⁺ could contribute to understanding of its pharmacokinetics and pharmacodynamics. Parameters of the static and dynamic fluorescence quenching of PPME-Cu²⁺ association were calculated at different temperatures. For binding site of 1:1 at 299 K, the static binding constant (k_S), the static isosbestic concentration (), the dynamic binding constant (k_D), and the dynamic isosbestic concentration () are, respectively, 61 M^-1, 0.0164 M, 75 M^-1, and 0.0133 M. The concentrations and efficiencies of the intermediates species were modeled. Satisfactory correspondence between the experimental and calculated results was found.

Two novel axially-substituted asymmetric silicon (IV) phthalocyanines, the first one substituted with both polyethylene glycol and indomethacin groups (Pc1) and second one substituted with both polyethylene glycol and mefenamic acid groups (Pc2) have been designed and synthesized for the purpose of pH sensing examinations. Their absorption and fluorescence emission-based spectral properties were investigated in chloroform, tetrahydrofuran and toluene. The pH-sensing properties of Pc1 and Pc2 were examined in detail by using UV-vis absorption and fluorescence spectroscopies in tetrahydrofuran. The effects of the substituents on the spectroscopic properties and pH-sensing behavior of these silicon phthalocyanines were revealed. Pc1 didn’t show a pH response; however, Pc2 exhibited a signal increase from pH 5.40 to 0.37 (turn on) and a drastic quenching when pH went from 0.37 to 5.40 (turn off). The protonation/deprotonation stage of the NH group of Pc2 presented fluorescence-based “on-off” type molecular switch properties.