Narrow Results

We report a straightforward synthesis of superparamagnetic Janus Polystyrene/Fe₃O₄@Silica ternary nanocomposites via a one-pot miniemulsion approach. The nanocomposites are dual functionalized simultaneously on the same physical carrier, with the carboxyl groups on the polystyrene surface while the silica region is functionalized with silano. With such a unique dual surface structure, it is possible to selectively functionalize multiple surfaces of a single carrier nanoparticle. Multifunctionality can be more readily achieved by this approach for biomedical applications. In this experiment, Doxorubicin is loaded on the silica region, as the model drug, for controlled release via a pH-responsive triggering mechanism. Meanwhile, the polystyrene surface is available for conjugating cancer-specific markers, which is needed for cell targeting. Also discussed are the reaction mechanisms and the key processing parameters in the synthesis of Polystyrene/Fe₃O₄@Silica nanocomposites.

Magnetic anisotropic particles, including Janus, patchy and multicompartment particles, have been particularly of great interest due to their magnetic response and anisotropy potential application in a wide variety of fields. Some strategies and techniques have been used to fabricate magnetic anisotropic particles. In this chapter, one of the main intension is to impart information about achievements on fabrication strategies and techniques of magnetic anisotropic particles in the last several years. A special emphasis will be made on several facial and scalable techniques. Some applications of these magnetic anisotropic particles are also introduced.