Human resources for health (HRH) play a central role in the delivery of health care services. Global health policymakers need to understand the key factors that impact HRH, because shortages adversely impact population health and surpluses inefficiently consume a country's resources. This chapter describes key issues surrounding the global health workforce and HRH planning. It begins by describing the HRH workforce and the supply of HRH workers across countries by income level. An economic framework of supply and demand is presented, along with the factors that affect the demand for and supply of HRH. The chapter then delves into the challenge of ensuring that HRH are well distributed across and within countries, including the issue of international migration. Next, it discusses the roles of the public sector, private sector, and donor organizations in HRH planning. Although, there has been significant progress over recent decades in the development of HRH severe shortages and maldistribution remain. Moreover, the future workforce will need to be designed to meet the care needs of an aging population that will become increasingly burdened by chronic conditions and mental health disorders. These trends require proactive HRH planning by global health policymakers.