Amphoteric hydrogels have been widely used in biologic and mechanic areas such as robot joints, biological cells, drug delivery systems. There are many factors that can influence the deformation of hydrogels, such as pH value, concentration of salt ions, solid constrains and external force, which all together makes the calculation very complicated. In this paper, an improved model for the calculation of amphoteric pH-sensitive hydrogels’ deformation is developed so that the behaviors of hydrogels in both acidic and alkaline solutions can be described quantitatively, and this model is implemented into finite element method (FEM) software ABAQUS in order to simulate hydrogel’s homogeneous and inhomogeneous deformations. The FEM results under free swelling state are compared with both analytical solution and FEM results existed before, and FEM results fit well with the experimental data. The buckling of amphoteric pH-sensitive hydrogel membrane is also analyzed, some natural phenomena, such as the wrinkling of human finger’s skin and the broad bean testa are successfully explained.