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The essence of the current examination is to carry out thermofluid parametric sensitivity with time-varying thermal migration of chemically reactive tiny species across an oscillating infinite plate surface. The impact of thermal motile tiny particles under the influence of many other oscillating flow parameters has yet to be investigated; hence the results obtained in this research are novel. Using a suitable non-dimensional variable, the leading PDEs (partial differential equations) are transmuted into dimensionless PDEs, ensuring equations are numerically solved using the MAPLE built-in approach. The numerical values produced in a limited scenario are linked with the outcomes found in the literature to validate the precision of the numerical approach utilized. The fluctuations in the profiles of the velocity, temperature, and concentration, in addition to the wall friction and rate of thermal and solutal transport, are illustrated via graphs and tables due to the modification of the critical parameters. The endmost results of the study concede that increasing permeability quantity and thermal and solutal buoyancy impellers intensify the fluid velocity. In contrast, a converse tendency is perceived with magnetic parameter and also, wall friction acts opposite to the velocity. The fluid temperature attenuated with dilation of the Prandtl number and radiation parameter, whilst a contrary trend was perceived with Eckert number. The increasing thermo-diffusion helps to develop fluid concentration whilst the Schmidt number and chemical reaction displayed opposite trend. Further, we achieved a tremendous conformity between the current findings and genuine results in the literature.