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A commercial application of the World-Wide Web concepts is described. It is shown how it is possible to solve a real customer problem in a rapid and cost-effective way by means of the WWW framework. The application has been developed at the Library Center of the University of Bologna (CIB).

Asia's Medical Technology Start-ups Get New Fast Track to Market via Partnership between Cambridge Consultants and Clearbridge Accelerator

Mitsubishi Electric and Sembcorp Industries to Testbed Novel Ozone Backwashing Energy-Saving Membrane Bioreactor

LEO Pharma Enters Biologics through Strategic Partnership with AstraZeneca

Bayer and X-Chem Expand Drug Discovery Collaboration to Discover Novel Medicines

New Gas Chromatography System Brings Power of Orbitrap GC-MS Technology to Routine Applications

A*STAR and MSD Establish a New Research Collaboration to Advance Peptide Therapeutics

Stem Cells Engineered to Grow Cartilage, Fight Inflammation

Combinatorial libraries of substituted tetrapyrrole macrocycles, which can now be prepared via a variety of approaches, typically are rich in isomers. Terminology for describing such isomers (due to distinct patterns of peripheral substituents) is delineated in several illustrative examples. A hierarchical relationship exists of molecular formula, condensed formula(s) of substituents, set(s) of pyrrole collocates (conveying each pair of β-pyrrolic substituents), and isomers of substituted tetrapyrrole macrocycles. Isomers with identical pyrrole collocate sets can arise owing to distinct positions or orientations of the (homo- or hetero-substituted) pyrrolic units in a macrocycle. Consideration of a handful of virtual combinatorial libraries illustrates tradeoffs of library size, chemical richness, and isomeric content. As one example, octa-derivatization of a tetrapyrrole scaffold with eight reactants A–H affords 2,099,728 members (99.7% isomers, 82,251 pyrrole collocate sets, and 6,435 condensed formulas) whereas the reversible self-condensation of four pyrroles that bear the same eight entities (AB, CD, EF, GH) affords 538 members (93.5% isomers, 35 pyrrole collocate sets, and 35 condensed formulas). Derivatization affords all combinations and permutations whereas self-condensation of substituted pyrroles carries collocational restrictions. Understanding such tradeoffs and the structural origin of isomerism are important aspects in the design of tetrapyrrole combinatorial libraries.

Since the last two decades, Wageningen UR Library has been involved in bibliometric analyses for the evaluation of scientific output of staff, chair groups and research institutes of Wageningen UR. In these advanced bibliometric analyses several indicator scores, such as the number of publications, number of citations and citation impacts, are calculated. For a fair comparison of scientific output from staff, chair groups or research institutes (that each work in a different scientific discipline with specific publication and citation habits) scores of the measured bibliometric indicators are normalized against average trend (or baseline) scores per research field. For the collection of scientific output that is subjected to the bibliometric analyses the repository Wageningen Yield (WaY) is used. This repository is filled from the research registration system Metis in which meta data for scientific output is registered by the secretaries of the research groups of Wageningen UR. By the application of a connection between the meta data of publications in WaY and citation scores in Thomson Reuters' Web of Science, custom-made analyses on the scientific output and citation impact of specific entities from Wageningen UR can be performed fast and efficiently. Moreover, a timely registration of new scientific output is stimulated (to ensure their inclusion in future bibliometric analyses) and the quality of meta data in WaY is checked by the library staff and research staff from the research entities under investigation, thus promoting communication between the library and customers.

A Digital Object Identifier (DOI) is an alpha-numeric standard for the use of identifying intellectual property within computer networks and is a recent trend in the field of the electronic publishing of scholarly articles. This study examines the publishing patterns in the scholarly literature of digital object identifiers. The research includes core journals, professional affiliations, gender, and geographic locations. Additionally, the primary disciplines represented in the authorship of the DOI literature are observed. This paper was submitted in the LIS651 course, Introduction to Library and Information Science, during April 2007, as a partial requirement for a Master's degree in the School of Library and Information Science, at the University of Southern Mississippi, Hattiesburg.