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Circulating tumor cells (CTCs) are malignant cells that are derived from a solid tumor in the metastasis stage and are shed into the blood stream. These cells hold great promise to be used as liquid biopsy that is less aggressive than traditional biopsy. Recently, detection and enumeration of these cells has received ever-increasing attention from researchers as a way of early detection of cancer metastasis, determining the effectiveness of treatment and studying the mechanism of formation of secondary tumors. CTCs are found in blood at low concentration, which is a major limitation of isolation and detection of these cells. Over the last few years, multifarious research studies have been conducted on accurate isolation and detection and post processing of CTCs. Among all the proposed systems, microfluidic systems seem to be more attractive for researchers due to their numerous advantages. On the other hand, recent developments in optical methods have made the possibility of cellular studies at single-cell level. Thus, accuracy and efficiency of separation, detection and manipulation of CTCs can be improved using optical techniques. In this review, we describe optical methods that have been used for CTC detection, manipulation and post processing.
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For the month of December 2020, APBN features article contribution from variety of writers. In the Features we take a dive into how COVID-19 vaccines could be shipped worldwide in an article by Kawal Preet, President of Asia Pacific, Middle East and Africa (AMEA) region for FedEx. For the Columns section, explore the transformations in telehealth and telemedicine in the Asia Pacific region. Also, writers from ACT Genomics discuss how liquid biopsy could provide potential in replacing tissue biopsy in genomic alteration profiling. For this month in the Spotlights, are highlights from the recent APACMed Virtual Forum 2020 on how technology is changing the landscape of healthcare. Finally, Professor Nadey Hakim, a general surgeon and currently the vice president of the Royal Society of Medicine weighs in on the recent release of data on the study for Sputnik V vaccine against COVID-19.
For the month of March 2021, APBN takes a look at these aspects in our features section. We explore the potential use of loop-mediated isothermal amplification assay (LAMP) in molecular diagnostics in an article written by Mark Carascal, a scientist, science illustrator, and science communicator advocate. Also, in the Features section, we look at the rising prevalence of genetic disorders as well as gene editing technologies across the world in an article contribution by Saloni Walimbe. In our Columns section, we evaluate the sufficiency and feasibility of current policies in protecting patient health data and how there is room for improvement. Gain insight to how to improve healthcare access in a sustainable way in Thailand through closer collaboration between organizations. The Spotlights section for this month sheds light on a variety of topics, first we look at liquid biopsies as a cancer diagnostic tool in ensuring proper treatment in an interview with Dr Steven Olsen, CMO at Guardant Health AMEA. In another interview with Dr Agnes Siew Ling Tey, Senior Clinical Scientist, Nutrition R&D Centre for Asia Pacific, Abbott on the recent Phase Two findings from the SHIELD study on nutrition in the elderly. Finally, we share highlights from the ISPE Singapore Conference and Exhibition held in November 2020.