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Let R be a prime ring with a nontrivial idempotent. In this paper, we prove that if g is an additive map of R into itself such that xg(y)z = 0 for all x, y, z ∈ R with xy = yz = 0, then g is a generalized derivation. As an application of this result, we show that every local generalized derivation in a prime ring with a nontrivial idempotent is a generalized derivation.