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This paper describes a longitudinal study to analyze the effects of acoustic stimulation with Binaural Beats (BBs) at 14Hz (beta band) in patients with Parkinson’s Disease (PD). Participants ($n=12$, age $58.75\pm 10.71$, stage $2.17\pm 0.75$ Hoehn and Yahr scale) listened to binaural stimulation for 10min a day, 3 days a week, during six months and were assessed 3 times during this period using electroencephalography (EEG), cognitive (PD-CRS), quality of life (PDQ-39) and wearing-off (WOQ-19) tests. During each assessment (basal, and after 3 and 6 months), the relative power in theta band was analyzed before, during and after the stimulation. Focusing the analysis on the motor cortex, the results obtained have confirmed the initial hypothesis for the first session, but they have shown a habituation effect which decreases its efficiency with time. Also, different reactions have been detected among individuals, with some reacting as expected from the beginning, while others would react in an opposite way at the beginning but they have shown afterwards a tendency towards the expected outcome. Anyhow, the relative power of the theta band was reduced between the first and the last session for more than half of the participants, although with very different values. Subtle changes have also been observed in some items of the PD-CRS, PDQ-39 and WOQ-19 tests.

Traditional Chinese medicine (TCM), originated from China, is different from Western medicine in theory and practice. This study aimed to document the longitudinal trends and the patterns by demographical characteristics in the prevalence of TCM among the middle-aged and elderly Chinese population. This study used nationally representative longitudinal survey data from the China Health and Retirement Longitudinal Study (CHARLS), covering approximately 20,000 individuals in each panel survey from 2011 to 2018. The questions regarding medication use in the questionnaire was used to identify the TCM users. The prevalence of using TCM for treating chronic diseases among the patients with chronic diseases stabilized between 2011 and 2018, while the prevalence of TCM use for any purpose among the overall population climbed from 19.03% (95% CI 18.37% to 19.69%) in 2011 to 23.91% (95% CI 23.23% to 24.60%) in 2015. Moreover, the prevalence of TCM use for nonchronic conditions among the overall population increased during the same period as well. The TCM users were more likely to be females and city dwellers. The increasing prevalence of TCM use for any purpose among the overall population reflects the increasing influence and potentials of TCM by year. With the expected rising demand in TCM for the following decades in China, more clinical trials on safety and healthcare policy regarding TCM are merited in the future.

The goal of this paper is to identify the factors that precede and may cause sudden changes in the pace of growth of high-growth SMEs or gazelles. A retrospective longitudinal case study of seven high growth SMEs that had undergone a total of 14 sudden shifts in growth reveals that a number of events caused the changes of pace. Some were triggered by the entrepreneur's decisions while others resulted from events beyond his/her control. Management's motivation for growth was an important element and this motivation changed over time, being influenced by both success and problems associated with actual growth. The success of growth strategies also appears to depend on the firm's proximity to its client base and its ability to obtain the information required for sound decision-making. Lastly, the availability of tangible and intangible resources was found essential in allowing the company to seize growth opportunities and proximity to the business milieu may help accessing these resources.

Based on a model consisting of (1) indicators related to the entrepreneurial person, (2) resource/environment indicators, and (3) founding process indicators, this paper examines founding success (who ultimately started up a business?) and new venture success/failure (which businesses survived?) in nascent businesses. The study analyzes a sample of 227 nascent entrepreneurs in Austria observed over a period of seven years. We find that characteristics of the person (i.e., risk-taking) affect founding success, but not survival. At the same time, resource and environment aspects did not show an effect on founding success or survival. Finally, we find that aspects of the founding process serve to explain both founding success and survival.

The early years are seen as a crucial period for the survival of ventures and yet only a limited number of studies have focused on successful new ventures when studying capital structure. Furthermore, only a few studies have included longitudinal data, tracking ventures over time, or have elaborated on the difference between short-term and long-term debt ratios when studying capital structure. In this paper, hypotheses are developed, based on capital structure theories and literature on new venture financing, and are tested on longitudinal empirical data. Results of multivariate analysis, through structural equation modeling, reveals that: (1) asset structure assists in explaining the variance in capital structure; (2) explained variance in dependent variables is decreasing for each of the four years studied; and (3) multi-group analysis reveals that the determinants influence short-term and long-term debt differently in the first four years of venture existence. Implications of this study suggest that determinants of capital structure in new ventures require theorizing of its own and demand special attention in entrepreneurial policy-making.

This article examines the relationship between initial conditions and new venture performance. The study uses a longitudinal study of 92 new ventures in Beijing Overseas Students Pioneer Park at Haidian. This study finds that new venture performance is significantly impacted by the venture's initial conditions. Additionally, the effects of initial conditions are found to decrease as the entrepreneurial process continues. It is also found that new venture performance is impacted more significantly by factors relating to entrepreneurial quality and characteristics of the venture.

This research paper examines the relationship between intellectual capital, product innovation and performance based on a study of Austrian firms covering a 10-year period. It is argued that intellectual capital enhances a firms ability to successfully realise innovations and thus contributes positively to its performance. Our study found that human capital and structural capital were both significantly associated with performance in product innovating firms, but that each had a different impact on this performance. While human capital had a positive impact on profitability and growth in the long run, contrary to expectations, structural capital had a negative effect on profitability and growth indicating that apparent strength can turn into a weakness over time. In addition, the study found that human capital and structural capital had no joint effect on the performance of product innovating firms.

This paper examines the roles of external stakeholders in the business model development of new technology-based firms (NTBFs) from the perspective of the founders. Based on a longitudinal study of two Swedish NTBFs, semi-structured interviews, including timeline mapping, were conducted with the founders of each firm over a period of two years, drawing on retrospective data from the first year of founding. The findings reveal that stakeholder interaction is first initiated based on the position the stakeholder has in relation to the firm, whereas what tasks the stakeholder perform in relation to NTBF resource needs has greater consequences for the business model development. The roles of stakeholders further help shape founder perceptions of how to do business, although such influence may be limited over time. The results provide valuable insight into the influence of founders’ perceptions and firms’ business networks on the business configuration of NTBFs, revealing that business model development is both endogenous and exogenous. Specifically, the study provides some original insights around which roles stakeholders play in the early development of the business model and why these roles are necessary at certain points in time.

This research paper examines the relationship between intellectual capital, product innovation and performance based on a study of Austrian firms covering a 10-year period. It is argued that intellectual capital enhances a firms ability to successfully realise innovations and thus contributes positively to its performance. Our study found that human capital and structural capital were both significantly associated with performance in product innovating firms, but that each had a different impact on this performance. While human capital had a positive impact on profitability and growth in the long run, contrary to expectations, structural capital had a negative effect on profitability and growth indicating that apparent strength can turn into a weakness over time. In addition, the study found that human capital and structural capital had no joint effect on the performance of product innovating firms.

This research paper examines the relationship between intellectual capital, product innovation and performance based on a study of Austrian firms covering a 10-year period. It is argued that intellectual capital enhances a firms ability to successfully realise innovations and thus contributes positively to its performance. Our study found that human capital and structural capital were both significantly associated with performance in product innovating firms, but that each had a different impact on this performance. While human capital had a positive impact on profitability and growth in the long run, contrary to expectations, structural capital had a negative effect on profitability and growth indicating that apparent strength can turn into a weakness over time. In addition, the study found that human capital and structural capital had no joint effect on the performance of product innovating firms.

This chapter describes Singapore's participation in the international comparative study on the teaching and learning of mathematics, known as the Kassel Project. The study was a longitudinal one, and entire cohorts of Secondary 2 pupils in 1995 from seven secondary schools in Singapore participated. The study monitored the individual progress of pupils relative to groups of pupils with similar potential and initial attainment in mathematics over a period of two years. The use of the data collected was two fold. At the national level, it led to recommendations for mathematics teaching in Singapore secondary schools, and at the international level it contributed towards the international database that was used to discuss issues in mathematics curriculum, mathematics teaching and learning in the participating countries.

A total of 856 primary school pupils from Singapore participated in the International Project on Mathematical Attainment (IPMA) from 1999 till 2003. The performance of the pupils in a test administered at the beginning of their primary schooling showed that they generally enter Primary 1 with considerable knowledge in arithmetic. From subsequent annual tests over a period of five years, it was found that they generally had a good grasp of the knowledge and mastery of skills that they were taught at school. Low attaining Primary 1 and 2 pupils were likely to be less attentive when the teacher was teaching and were also easily distracted. They were often not on task during groupwork or individual seatwork. From lesson observations, it was apparent that nearly all the mathematics lessons were structured with specific learning objectives. The study also revealed some weaknesses in the teaching of primary mathematics in Singapore, particularly in representation, making connections, and communication of mathematical ideas.