In this paper, we introduce a new notion of module strong pseudo-amenability for Banach algebras. We study the relation between this new concept to other various notions at this issue, module pseudo-contractibility, module pseudo-amenability and module approximate amenability. For an inverse semigroup S with the set of all idempotents E, we show that ℓ1(S) is module strong pseudo-amenable as an ℓ1(E)-module if and only if S is amenable. For specific types of semigroups such as Brandt semigroups and bicyclic semigroups, we investigate the module strong pseudo-amenability of ℓ1(S). We show that for every non-empty set I, 𝕄I(ℂ) under this new notion is forced to have a finite index as an 𝔄-module, where 𝔄={[ai,j]∈𝕄Λ(ℂ)|∀i≠j,ai,j=0}.