The spreading of the four main families of classical orthogonal polynomials of a discrete variable (Hahn, Meixner, Kravchuk and Charlier), which are exact solutions of the second-order hypergeometric difference equation, is studied by means of some information-theoretic measures of global (variance, Shannon entropy power) and local (Fisher information) character. The variance is calculated in a closed an compact form by means of the three-term recurrence relation of the polynomials. Then, the Cramer-Rao and Heisenberg-Shannon inequalities are used to find rigorous bounds for the other two measures.