This chapter provides glimpses of the historical, cultural and scientific elements that serve as the philosophical and scientific foundation for exploring and interpreting the Mereon Matrix, in particular the Mereon Trefoil. Numbers, symbols and forms found in natural systems were investigated relative to how they have been employed throughout history to communicate or encapsulate knowledge, helping to form or dismantle social systems. This review ranges from Galilei to Hawkins, linking Euler to Fibonacci and Φ. It reveals overlaps in philosophy and form, connecting astrology to cymatics and linking a 70,000-year-old stone carved in geometry to the architectural rule of Sullivan’s Law. The Mereon Matrix offers a new perspective on completeness and sustainability, and therefore, a call is made for transdisciplinary investigations to improve how humans use the resources that our universe provides and how we must expand our ability to preserve them.