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MicroRNAs, small non-coding RNA molecules, have gained a reputation of the most substantial regulators in gene network with the ability to down-regulate their targets. Accumulating evidence shifted insight toward microRNAs regulation as the key element of cancer initiation, development, and aggression. Recent studies have attached the importance of traditional Chinese medicine (TCM) to the treatment of various cancers, and the functional natural compounds have been considered as novel anticancer agents to directly inhibit tumor progression. In more recent decades, a wide range of biologically active components of TCM has gained increasing attention to their applications in the modulation of microRNAs. This review is on the purpose of demonstrating the significance of TCM bioactive ingredients in microRNAs regulation for cancer treatment according to the reports mainly in the recent six years, providing the evidence of efficient Chinese herbal medicine-based therapy and effective pro-diagnosis focusing on microRNAs expression of cancer patients.

South Korean Scientists Develop Tailored Stem Cells to Treat Individuals.

New Antiviral Therapy for Avian Influenza.

MicroRNAs as Oncogenes?

Sharp's Plasmacluster Ions Effectively Deactivate H5N1 Avian Influenza Virus.

Professor David P Bartel and His Contributions to the Discovery of microRNAs.

Psoriasis is a complex disease, in which microRNAs played an important role in regulating target genes, and thus affecting gene expression and conducting cell proliferation. To analysis the regulation of microRNAs, and to illustrate the interaction of microRNAs with psoriasis related genes, we analyzed the upstream regions of the differentially expressed microRNAs relating to psoriasis. The polymerase binding site motifs were discovered by MAST using profiles of 13 polymerases in the upstream region for each microRNA, and a SVM (Support Vector Machine) was used to identify the motifs mostly related to microRNA expression level. Result shows that motif 3 and motif 6 are key to the gene expression type of psoriasis related microRNAs.