Lattice knots have been studied in recent years, especially in ℤ3 and with respect to how many edges are required to form a knot. Knots formed from cubes have also been investigated for their ability to tessellate space. In this article, we demonstrate that there is a relationship between the minimum number of edges required to form a lattice knot and the minimum number of cubes required to form the same kind of knot. We further investigate the relationship in the face-centered cubic lattice.