The main purpose of this paper is to investigate parallel frames of non-lightlike curves in Minkowski space-time. For this purpose, the relations between Frenet–Serret frame and parallel frame of a given non-lightlike curve are discussed in four different cases. Then, the curvature, first and second torsion functions κ(s), τ(s), σ(s) and principal curvature functions k1(s), k2(s), k3(s) are expressed in terms of the angles α, β and θ.