Let RR be a prime ring of characteristic different from 22, QrQr be its right Martindale quotient ring and CC be its extended centroid, αα be an automorphism of RR, dd be a skew derivation of RR with associated automorphism αα, FF and GG be two nonzero XX-generalized skew derivation of RR with associated term (b,α,d)(b,α,d) and (b′,α,d), respectively, S be the set of the evaluations of f(x1,…,xn) on R, where f(x1,…,xn) is a non-central multilinear polynomial over C in n non-commuting variables. Let 0≠v∈R be such that F(x)x+G(x)xv=0 for all x∈S. Then one of the following statements holds :
- (a)f(x1,…,xn)2 is central valued on R and there exist a,a′∈Qr such that F(x)=ax, G(x)=a′x for any x∈R with a+a′v=0;
- (b)v∈C and F=−vG.
In the last part of the paper, we present some applications on the basis of the foregoing proposed result.