The developed spherical plasma focus model is used in this study to investigate the optimum neutron yield in terms of the gas pressure, cathode radius and external inductance. The optimum values for these parameters are found separately. Then, the charging voltage is varied from 25kV to 35kV with 1kV increment by using these separately found optimum values to see the rate of increase in neutron yield. While the used gas pressure range is 1–40Torr with 1Torr increment, cathode radius range is 11.5–17cm with 0.5cm increment. External inductance is varied from 10nH to 150nH with 5nH increment. The optimum values for gas pressure, cathode radius and external inductance are found to be 26Torr, 15cm and 75nH, respectively. Even though combining these separately found optimum values of pressure, cathode radius and external inductance does not necessarily form an optimized set of operational conditions for the SPF, they lead to a higher neutron yield in that while neutron yield with these separately found optimum values at 25kV charging voltage is 2.82×10132.82×1013 (higher than the measured neutron yield of 1.26×10131.26×1013 at 25kV), it increases to 1.32×10141.32×1014, when charging voltage is increased to 35kV. Using these values shows that spherical plasma focus device can be used as a neutron source with high neutron yield (on the order of 10141014).