Let GG be any group and GG be a subgroup of Sym(Ω)Sym(Ω) for some set ΩΩ. The 22-closure of GG on ΩΩ, denoted by G(2),ΩG(2),Ω, is by definition,
{𝜃∈Sym(Ω)|∀α,β∈Ω,∃g∈G,α𝜃=αg,β𝜃=βg}.{θ∈Sym(Ω)∣∣∀α,β∈Ω,∃g∈G,αθ=αg,βθ=βg}.
The group GG is called 22-closed on ΩΩ if G=G(2),ΩG=G(2),Ω. We say that a group GG is a totally22-closed group if H=H(2),ΩH=H(2),Ω for any set ΩΩ such that G≅H≤Sym(Ω)G≅H≤Sym(Ω). Here we show that the center of any finite totally 2-closed group is cyclic and a finite nilpotent group is totally 2-closed if and only if it is cyclic or a direct product of a generalized quaternion group with a cyclic group of odd order.