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  • articleNo Access

    Automatic classification of lung tumour heterogeneity according to a visual-based score system in dynamic contrast enhanced CT sequences

    Computed tomography (CT) technologies have been considered for a long time as one of the most effective medical imaging tools for morphological analysis of body parts. Contrast Enhanced CT (CE-CT) also allows emphasising details of tissue structures whose heterogeneity, inspected through visual analysis, conveys crucial information regarding diagnosis and prognosis in several clinical pathologies. Recently, Dynamic CE-CT (DCE-CT) has emerged as a promising technique to perform also functional hemodynamic studies, with wide applications in the oncologic field. DCE-CT is based on repeated scans over time performed after intravenous administration of contrast agent, in order to study the temporal evolution of the tracer in 3D tumour tissue. DCE-CT pushes towards an intensive use of computers to provide automatically quantitative information to be used directly in clinical practice. This requires that visual analysis, representing the gold-standard for CT image interpretation, gains objectivity.

    This work presents the first automatic approach to quantify and classify the lung tumour heterogeneities based on DCE-CT image sequences, so as it is performed through visual analysis by experts. The approach developed relies on the spatio-temporal indices we devised, which also allow exploiting temporal data that enrich the knowledge of the tissue heterogeneity by providing information regarding the lesion status.

  • articleNo Access

    Industry Watch

      HD Medical and CSIRO Collaborate on Cardiac Diagnostics.

      Medical Therapies Collaborates with NexMed.

      Progen's Inventory Results on Phase 2 Liver Cancer Trial.

      Renhuang Pharmaceuticals Announces Government Grant.

      Mindray Medical to Establish New R&D and Manufacturing Base in Nanjing.

      Sterlin Gelatin to Expand in India and China.

      Favorable Decision Granted to Ranbaxy Laboratories on Pfizer's Australian Atorvastatin Patent.

      Honeywell Automation India Ltd Plans to Expand into Emerging Indian Pharma Sector.

      Bharat Biotech Launches Anti Rabies Vaccine — Rabirix.

      Caliper Life Sciences Announces Expanded Sales on LabChip and Ivis.

      Japan's Bioventures Today — ImmunoFrontier, Inc.

    • articleNo Access

      Industry Watch

        Progen Expands Drug Development Pipeline through Acquisition of CellGate.

        Morphotek Announces Collaborative Research Agreement with Ludwig Institute for Cancer Research.

        Crucell Enters Agreement with Sanofi Pasteur for Biologicals against Rabies.

        Cellworks Announces Drug Discovery Collaboration with Orchid Based on Systems Biology Technology.

        ILS Partners with Wistar.

        CardioDynamics International Corporation (CDIC) Announces Strategic Alliance with Leading Medical Equipment Manufacturer in India.

        Biocon and IATRICa Partner to Develop Novel Immunoconjugate Therapeutics against Cancer and Infectious Diseases.

        GSK Launches 2 DTP Vaccines in India.

        BIOBASE Opens New Subsidiary Nihon BIOBASE KK in Yokohama.

      • articleNo Access

        Industry Watch

          Arana Achieves Milestone in Collaboration with CSL Limited.

          BI Biotech India and GlobalStem Inc Partner to Provide Stem Cell Research Tools in India.

          Zydus Cadila and Prolong Pharmaceuticals Collaborates in Drug Discovery and Development.

          Amgen and Takeda Announce Exclusive Collaboration in Japan.

          Bausch & Lomb and CrystalGenomics Announce R&D Collaboration.

          Emergent BioSolutions (EBS) and Ninebio Sdn Bhd Announce Joint Venture in Malaysia.

          Syngene Installs the First G: BOX HR Gel Documentation System in Jurong Island, Singapore.

          Swiss Biopharmaceutical Actelion Opens Regional Office in Singapore.

        • articleNo Access

          Industry Watch

            Invitrogen Enters into a Licensing Agreement with IMBcom.

            Stem Cell Sciences Enters into an Agreement with Myelin Repair Foundation.

            European Company NovaSecta Joins First Chinese CRO Service Alliance for Drug Discovery Solutions.

            DuPont (DD) Opens Fluoropolymer Production Plant in China.

            Satyam Opens Center to Cater to Life Sciences Industry.

            Eisai and Accenture Launch Clinical Data Management in India.

            Sanofi Pasteur and Statens Serum Institute Team Up against Tuberculosis.

            Roche Diagnostics and Mankind Pharma Collaborate on Accu-Chek Go.

            Nicholas Unit Signs Drug Development Pact with Eli Lilly & Co.

            Pierre Fabre and Nicholas Piramal Sign Oncology Research Agreement.

            Fortis HealthWorld Works with Godrej Aadhaar to Reach Out to Rural Areas in India.

            Karo Bio and Zydus Cadila Sign Research Agreement.

            ICGEB Joins with Emory Vaccine Center.

            DiscoveRx Corporation Signs Agreement with Cosmo Bio.

            Sysmex and bioMérieux Form Commercial Joint Venture for the Japanese In Vitro Diagnostics Market.

            Progeniq Launches Next-generation BioBoost v4.0 Accelerator.

            Celltrion and CSL Announce Collaboration to Develop and Manufacture Monoclonal Antibody.

            Antitope Ltd Announces Research Agreement with China Synthetic Rubber Corporation.

            Merck and DCB Announce Cooperation to Create New Biotech Services and Training Center.

            Taiwan's PharmaEssentia Signs Deal with Malaysia's Black Gold Global.

          • articleNo Access

            Industry Watch

              Driving Stem Cell Technology Forward – Stem Cell Sciences In-licenses Technology from University of Cambridge for Reprogramming Adult Cells into Stem Cells.

              The Latest State-of-the-art Clinical Trial Supply Service Center Opens in China.

              Charles River Strengthens Its Presence in China.

              In the Making – China Biologic to Become Largest Non-state-owned Producer of Plasma-based Products in China.

              Joint Venture between Eli Lilly and Jubilant Organosys Boosts Development of Molecules.

              From Discovery to Delivery – Orchid & Merck Collaborate to Develop Novel Anti-infective Drugs.

              New Standard for Early Diagnosis of Urinary Bladder Cancer Launched.

              Gene Bridges Granted Licenses to Takeda Pharmaceuticals Licenses for Recombineering Technology.

              East-West Collaboration to Develop Therapeutics for Fully-human Antibody Program.

              The Kiwis Open Commercialization Pathway into the Land of Dragons.

              Innovative Institute-Industry Partnership in Translational Cancer Research.

              Singapore to be the Takeda's Center of Clinical Development.

              First South-east Asian Hub for Solar PV Testing and Certification Opens in Singapore.

            • articleNo Access

              Industry Watch

                Alchemia Collaborates on SK1.

                Progen Technology Switches On Cancer Fighting Genes.

                New Australian Drug Holds Hope of Major Breakthrough in Treating Terminal Blood Cancers.

                Novavax and Cadila Pharmaceuticals Form Alliance.

                Icon's Singapore, India Labs Get CAP Accreditation.

                SIRO Clinpharm and Advanced Clinical Trial Solutions Form Strategic Alliance.

                GVK Forays into Clinical Trials with Chinese Company.

                iZumi Bio and Kyoto University Collaborate on iPS Cell Technology.

                Vitrolife Starts a Company in Japan.

                Otsuka, BMS in an Oncology Collaboration.

                EnVivo, Mitsubishi to Develop Schizophrenia Drug.

                PerkinElmer Announces Collaboration with Sangmyung University.

                Living Cell Technologies's New Zealand Pigs Free of Viruses.

                A*STAR Joins Forces with Swiss Company, Cytos, to Combat HFMD.

                IBN Engineers World's First Tri-Continuous Mesoporous Silica.

                Innogene Kalbiotech Pte Ltd and Info Kinetics Sdn. Bhd. Spearhead Establishment of Internationally Accredited BA/BE Studies in Indonesia.

              • articleNo Access

                People Watch

                  NCCS Oncologist Receives Prestigious Award.

                  Dr Michael Entzeroth Reelected as Chairman of BioSingapore.

                  India's Biotech Queen Wins Nikkei Asia Prize 2009.

                • articleNo Access

                  Industry Watch

                    Research Institute and CSL to Develop New Treatments for Inflammatory Diseases.

                    QRxPharma in Strategic Alliance with Liaoning Nuokang Medicines for the Development of Venomics Assets.

                    Mesoblast's Treatment for Damaged Intervertebral Disc Cartilage may be a Product Breakthrough.

                    Device Technologies Australia in Strategic Partnership with Health Robotics for Robot-Assisted Cancer Surgery.

                    Agilent Technologies Co-Establishes Center for Systems Biology with Chinese Academy of Sciences.

                    Zhejiang Hisun Pharmaceutical Granted License to Develop Hematopoietic Stem Cell Stimulator.

                    HUYA Establishes Partnership with GIBH.

                    China Biologic Products Enters into a Strategic R&D on Blood Plasma.

                    India's First Stem Cell Therapy Laboratory Launched.

                    Biocon and Amylin to Jointly Make Drug for Diabetes.

                    Singapore Sets up First Cell Therapy Facility.

                    Smart Information Technology Integration for Bangkok Hospital Group.

                  • articleNo Access

                    Industry Watch

                      Australian Company Develops Potential UV Vaccine.

                      Phylogica Enters Agreement with Roche to Evaluate Phylomer Technology.

                      CSL Behring Awards $87,000 to Patient Organizations in USA.

                      Pfizer, Crown Bioscience Tie up for Asian Cancers R&D.

                      Sinovac Files Clinical Trial Application with SFDA for Vaccine against Hand, Foot, and Mouth Disease.

                      Takeda and Pfizer to Co-Promote Takeda's Actos® (pioglitazone HCl) for the Treatment of Type 2 Diabetes in China.

                      Alvogen Launches Asia Operations.

                      Praj to Collaborate with Novozymes on Advanced Biofuels.

                      Biocon and HCG Group of Hospitals Join Hands to Fight Against Cervical Cancer.

                      Shantha Introduces India's First Oral Cholera Vaccine.

                      Pfizer, TCGLS to Develop Preclinical Candidate Molecules.

                      Hospira to Acquire Orchid's Generic Injectable Pharmaceuticals Business.

                      Dicerna Pharma, Kyowa Hakko to Collaborate on RNAi.

                      Ambit Biosciences and Astellas Enter Strategic Partnership.

                      Inno Biologics, CEVEC for Using Sign Agreement Human CAP Technology.

                    • articleNo Access

                      Industry Watch

                        Benitec Limited Granted Hepatitis C RNA Interference Patent in US.

                        HUYA Bioscience International and China Medical City Forge Alliance.

                        Chindex, Fosun Pharma Form Joint Venture.

                        Daiichi Sankyo and Ranbaxy to Integrate New Drug Research and Development System.

                        TAKE Solutions and Reliance Life Sciences Enter Strategic Alliance.

                        Veeda Oncology Announces $8.4 million in New Business.

                        Medicago signs Vaccine MOU with PT Bio Farma.

                        Kyowa Hakko Kirin to Enter Out-licensing Agreement with Biovail.

                        Sosei to Acquire Activus Pharma.

                        Takeda to Expand Operations in South Korea.

                        SymBio and Cephalon Sign License Agreement.

                        Quintiles Announces Clinical Research Partnership with the University Malaya Medical Centre.

                        Roche's New DNA Sequencer Opens Innovation in Genomic Research.

                        Dow Microbial Control Academy Showcases Industrial Leadership and Expertise.

                      • articleNo Access

                        Industry Watch

                          Phylogica Commences Antimicrobial Peptide Discovery under Agreement with MedImmune.

                          Leadtec Systems Australia to Acquire Mimotopes.

                          Sirnaomics Seals Deal for Development of RNAi Therapeutics in China.

                          Simcere and Bristol-Myers Squibb Enter Innovative Partnership to Develop Early-Stage Oncology Compound.

                          Pfizer, Biocon in $350 Million Insulin Pact.

                          Bharat Biotech Announces Launch of 'HNVAC™' India's First Cell-Culture H1N1 Swine Flu Vaccine.

                          Cipla Launches the World's First Generic Pirfenidone in India, Giving Hope to Sufferers of IPF (Idiopathic Pulmonary Fibrosis).

                          Eisai and FORMA Therapeutics Enter into Broad Drug Discovery Collaboration.

                          Philips and Atom Medical Corporation Announce Strategic Alliance to Provide a Complete Neonatal and Perinatal Offering.

                          CiRA and France-based Cellectis Enter Collaboration.

                          Immunovaccine Signs Research Agreement with OncoTherapy Science to Advance Potential Cancer Vaccine.

                          Glycos Biotechnologies Enters Definitive Agreement with Malaysian Bio-XCell.

                          Biocon Plans to Invest $161m in Malaysia to Set Up R&D Unit.

                        • articleNo Access

                          INSIDE INDUSTRY

                            AtCor Signs US$0.9 Million Pharmaceutical Contract.

                            Corning Opens Life Sciences Manufacturing and Distribution Facility in China.

                            Roche NimbleGen and BGI Develop Advanced MHC Region Capture Technology.

                            GVK Biosciences Partners with PROOF Centre of Excellence.

                            Stemade Biotech Unveils Dental Stem Cell Banking in Chandigarh.

                            Israeli Firm to Hold Schizophrenia Clinical Trial in India.

                            Quintiles and Prodia Partner to Provide Central Lab Testing Solution in Indonesia.

                            Medtronic Begins Transcatheter Aortic Valve Trial in Japan.

                            Intellect Neurosciences Obtains Two New Patents in Japan for Alzheimer's Immunotherapy Programs.

                            ASLAN Pharmaceuticals and Bristol-Myers Squibb Enter Innovative Oncology Partnership.

                          • articleNo Access

                            INSIDE INDUSTRY

                              Cognoptix licenses AD detection technology.

                              3D cell culture firm Reinnervate and specialist Oncology CRO Oncotest GmbH enter collaboration agreement.

                              Medicago awarded contract from the U.S. Department of Defence.

                              Clinical Network Services acquires New Zealand partner BELTAS' business assets.

                              VABIOTECH licenses cell-based Japanese encephalitis technology from Inviragen.

                              University of Illinois licenses novel anti-cancer therapies to StemPar Sciences.

                              Adimab announces new discovery collaboration with Kyowa Hakko Kirin.

                              Priaxon enters collaboration with GSK on protein-protein-interactions.

                              Lantheus Medical Imaging and FUJIFILM RI Pharma renew long-term license and distribution agreement.

                            • articleNo Access

                              BIOBOARD

                                INDIA – Lack of access to technology ‘hampers detection of substandard drugs’.

                                JAPAN – Daiichi Sankyo announces development of nucleic acid treatment for Duchenne muscular dystrophy utilizing proprietary technology.

                                SINGAPORE – IBN creates unlimited source of human kidney cells.

                                SINGAPORE – Dyesol and Singapore's NTU sign agreement.

                                THE PHILIPPINES – Global biotech/GM crop plantings increase 100-fold from 1996.

                                AUSTRALIA – Phosphagenics further expands pain portfolio.

                                AUSTRALIA – Primary Health Care signs Australia distribution agreement for iGeneScreen™ prenatal test.

                                AUSTRALIA – Folic acid in pregnancy linked with reduced autism risk.

                                AUSTRALIA – Phylogica and Bio-Link collaborate to commercialize anti-inflammatory Phylomers.

                                AUSTRALIA – ABRAXANE® plus gemcitabine improves survival in Phase III study of patients with advanced pancreatic cancer.

                                CANADA – Verisante Technology, Inc. announces first sales of aura, a revolutionary medical device for the detection of skin cancer.

                                EUROPE – Project eyes robust medical technology for poor countries.

                                UNITED KINGDOM – Asthma sufferers have more lung fungi.

                                UNITED KINGDOM – Pioneering drug discovery gets major funding to move to next stage.

                                UNITED STATES – Gilead's sofosbuvir for hepatitis C meets primary endpoint in fourth pivotal Phase III study.

                                UNITED STATES – Eleven Biotherapeutics publishes data on EBI-005, a novel IL-1 inhibitor protein for topical treatment of dry eye disease.

                                UNITED STATES – Phase I/II trial of ADXS-HPV in anal cancer conducted by Brown University Oncology Group.

                                UNITED STATES – Scopolamine: An old drug with new psychiatric applications.

                                UNITED STATES – New bioengineered ears look and act like the real thing.

                                UNITED STATES – To trap a rainbow, slow down light.

                                UNITED STATES – AB SCIEX responds to milk contamination concerns with new method to detect dicyandiamide.

                              • articleNo Access

                                EYE ON CHINA

                                  ScinoPharm Taiwan and Coland Holdings establish strategic alliance for oncological injectable products for China.

                                  Researchers investigate the effects of thinning on soil respiration and its sensitivity in a pine plantation, eastern Tibetan Plateau.

                                  Ascletis gains China market rights from Janssen to a clinical stage HIV protease inhibitor.

                                  The genome sequences of soft-shell turtle and green sea turtle offer new clues to the development and evolution of turtle-specific body plan.

                                  Daiichi Sankyo launches Silodosin for the treatment of Dysuria in China.

                                  China plans research centres to aid developing world.

                                  HKU finds novel coronavirus can infect humans respiratory tract even better than SARS-CoV.

                                  BGI Health collaborates with Eastern Biotech & Life Sciences on non-invasive fetal Trisomy test for improving reproductive health in the Middle East.

                                  Baxter China partners with government to increase access to renal therapy.

                                • articleNo Access

                                  EYE ON CHINA

                                    Epigenomics and BioChain enter into broad strategic collaboration in China.

                                    China Sunergy's Head of Research wins 2013 ACAA/IELTS Australia China Alumni Awards.

                                    WuXi PharmaTech enters agreement for patient-derived xenograft models with Mayo Clinic's Center for individualized medicine.

                                    Merck enters into further global co-development and commercialization agreement for PARP inhibitor with Chinese R&D company BeiGene.

                                    Creganna-Tactx Medical opens office in China.

                                    Honeywell to modernize petrochemical plants in China.

                                    WuXi PharmaTech to partner with Pharmacyclics.

                                    Novozymes and M&G Chemicals to collaborate on biomass-based plastics in China.

                                    Catalent's Clinical Trial Supply Facility in Shanghai, China opens for business.

                                    Shanghai Institute of Materia Medica and Crown Bioscience to develop mouse clinical center and PDX and Translational Oncology Platform.

                                  • articleNo Access

                                    PEOPLE WATCH

                                    Collaborating for Oncology.

                                  • articleNo Access

                                    EYE ON CHINA

                                      Hepalink signs agreement to acquire Scientific Protein Laboratories.

                                      Yasheng Group joint venture with IBC International LLC to form Angel Star Nutrition LLC.

                                      Zynex signs distribution agreement for China market.

                                      Tao Li of China Green Agriculture, receives the honor of “Future Chinese Business Leaders”.

                                      Yingli Green Energy enters joint venture with Datong Coal Mine Group.

                                      Elekta wins public tender to deliver cancer care solutions to China.

                                      Stellar Biotechnologies Announces Collaboration with Amaran Biotechnology, Inc.

                                      TaiGen Biotechnology signed exclusive license agreement with R-Pharm for nemonoxacin (Taigexyn).

                                      Eddingpharm acquires global rights to oncology assets, including Telatinib, from ACT Biotech.

                                      BioLineRx and JHL Biotech to collaborate on Type 1 diabetes antibody treatment.

                                      Bayer and Peking University establish new research center for translational research and drug discovery in Beijing.

                                      Microport Scientific Corporation and Sorin Group sign joint venture agreement for cardiac rhythm management business in China.

                                      Epigenomics signs licensing and supply agreement with Kindstar for Epi proLung in China.

                                      Abcam to open office in Shanghai, China.

                                    • articleNo Access

                                      INSIDE INDUSTRY

                                        Lupus Research Institute awards $1-million grants to discover what causes lupus.

                                        AstraZeneca and Pharmacyclics enter clinical trial collaborations in oncology.

                                        Singapore — the global launch pad for game-changing clinical trials initiative.

                                        MedImmune strengthens immuno-oncology capabilities with acquisition of Definiens.

                                        AOP Orphan to bring Thromboreductin® to the Russian market.

                                        PPP launched to improve prevention of women's cancers and quality of cancer registries in Latin America and the Caribbean.

                                        National Heart Research Institute Singapore and Thermo Fisher Scientific team up to further enhance stem cell research techniques.

                                        Felicitex Therapeutics and Selvita initiate strategic collaboration to target cancer quiescence.

                                        WomenHeart launches first campaign to improve quality of life and reduce hospitalizations for women living with heart failure.

                                        President's Science and Technology Awards 2014 honors outstanding scientific talent for their contributions to Singapore's R&D landscape.