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Mitochondrial metabolism plays a crucial role in insulin resistance and insulin secretion in type 2 diabetes mellitus (T2D). Some studies have focused on how Cassia tora extracts affect insulin resistance and hyperglycemia. However, the effects of Cassia tora extracts on mitochondrial dysfunction associated with insulin secretion have not been well explained. In this study, well-known effective compounds extracted from Cassia tora using 70% ethanol were administered to a high-fat diet (HFD) fed mouse to examine the effects of Cassia tora ethanolic extracts (CSEE) on mitochondrial dysfunction in the pancreas. Furthermore, we examined how CSEE regulates the basal mechanism of insulin secretion through mitochondrial functions. Our experimental data suggest that pancreatic mitochondrial metabolism in HFD mice is enhanced to compensate for constrained glucose consumption. HFD-fed mice treated with CSEE showed improved pancreatic mitochondrial functions resulting in alleviation of insulin resistance at target tissue as well as basal hyperinsulinemia.

Nowadays, the role of the control system in the bioengineering field plays a major part due to its significant improvement and demand. Usually, if there are any changes in the parameter of a biological system, then it tends to cause crucial diseases in humans. Previously, various control algorithms have been developed; however, the proper control process failed due to the high error rate, slow convergence, Computational Complexity, Tuning Complexity and inaccurate function. The proposed control strategy should ensure accurate tracking of the desired trajectory or reference signal, even in the presence of uncertainties and disturbances. The control system should be capable of adapting to changes in the system dynamics and maintaining stable operation. This complexity can lead to high computational requirements, making the controller computationally expensive and potentially unsuitable for real-time applications or systems with limited computing resources. To overcome these issues, in this work, the novel Hybrid Ant Lion Moth Flame Optimization (HALMFO) based Backstepping Fractional-Order Sliding mode Proportional-Integral-Derivative (BFO-SPID) controller is proposed for different nonlinear biological systems. The proposed method enhances the efficiency, improved performance, robustness, convergence speed, and solution quality of the optimization process. This paper addresses the challenge of controlling nonlinear biological systems by proposing a novel hybrid optimization-based backstepping approach combined with a fractional order sliding mode proportional-integral-derivative (PID) controller. This work’s essential contribution lies in addressing existing control strategies’ limitations by integrating multiple control techniques to achieve robust tracking performance and disturbance rejection. This system proposes predictive control with state estimation based on the backstepping sliding mode method. The gain parameters of the developed controller are optimized using the HALMFO method. The proposed control approach performance has been tested under biological systems such as Protein, Pancreas, and Genetic Regulatory Network (GRN). The execution of this proposed model is done in MATLAB/Simulink. Furthermore, the performance of the proposed control technique is compared with various state-of-the-art methods in terms of accuracy, Mean Average Error (MAE), Mean Square Error (MSE), settling time, overshoot, and rise time. The comparison illustrates that the projected controller has reached a steady condition with the least error rate in the control application. Thus the developed controller regulates the parameter variations in the biological system as per the desired level, providing significant effective outcomes to complex problems.

Keep the weight off, keep diabetes at bay

Tackling obesity in ASEAN

The influence of ischemia–reperfusion (I/R) action on pancreatic blood flow (PBF) and the development of acute pancreatitis (AP) in laboratory rats is evaluated in vivo by using the laser speckle contrast imaging (LSCI). Additionally, the optical properties in norm and under condition of AP in rats were assessed using a modified integrating sphere spectrometer and inverse Monte Carlo (IMC) software. The results of the experimental study of microcirculation of the pancreas in 82 rats in the ischemic model are presented. The data obtained confirm the fact that local ischemia and changes in the blood flow velocity of the main vessels cause and provoke acute pancreatitis.