This study addresses a significant gap in the literature by extending the path integral formalism to time-dependent systems within the Wigner–Dunkl framework, deriving exact propagator solutions for analytically solvable cases. By employing generalized canonical transformations, we reformulated the path integral to develop an explicit expression for the propagator. This formalism is applied to specific cases, including a Dunkl-harmonic oscillator with time-dependent mass and frequency. Solutions for the Dunkl–Caldirola-Kanai oscillator and a model with a strongly pulsating mass are derived, providing exact propagator expressions and corresponding wave functions. These findings extend the utility of Dunkl operators in quantum mechanics, offering new insights into the dynamics of time-dependent quantum systems and possibly find application in quantum optics, plasma physics, and other fields.