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The aim of the present investigation was to evaluate the clinical efficacy of Kyuki-chouketsu-in, a Japanese traditional herbal medicine, in restoring postpartum physical condition. We enrolled 171 women who had a normal delivery in Osaka Medical College Hospital or its affiliated clinics, and randomly assigned them to the following two groups: a group of 85 women who received Kyuki-chouketsu-in at a dose of 6.0 g/day (Group K), and a group of 86 women who received ergometrine (methylergometrine maleate) at a dose of 0.375 mg/day (Group E). The height of the uterine fundus, blood hemoglobin concentration and biochemical blood values were determined until day 6 postpartum. The height of the uterine fundus was significantly lower in women of Group K (8.9 ± 2.4 cm) than in those of Group E (10.5 ± 2.7 cm) on day 5 postpartum (p = 0.071). A significant difference between Groups K and E was noted in change in blood hemoglobin concentration between days 1 and 6 postpartum (4.6 ± 7.2% in Group K; -1.57 ± 7.3% in Group E). Significant differences between Groups K and E were noted in decrease in serum C-reactive protein (CRP) concentration and increases in serum total protein (TP) and albumin concentrations between days 1 and 6 postpartum. No adverse effects were observed in this study. The results of our study demonstrate the beneficial effects of Kyuki-chouketsu-in on physical recovery in the postpartum period. Kyuki-chouketsu-in can be expected to improve the health of women in the postpartum period. Biopharmacological research and clinical trials to investigate the properties of this drug in detail are warranted.

This study was to evaluate the clinical efficacy of Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in), a Japanese traditional herbal medicine, in stabilizing postpartum psychological state. We enrolled 268 women who had a normal delivery in Osaka Medical College Hospital or its affiliated clinics and randomly assigned them to the following two groups: a group of 134 women who received Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) at a dose of 6.0 g/day and another group of 134 women without Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) (control group). We observed 2.06-fold and 1.67-fold higher incidences of depressive mood and nervousness, respectively, after delivery in the control group than in the Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) group. Within 3 weeks of postpartum, there was a significant difference in the incidences of maternity blues between the Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) group (15.7%; 21/134) and the control group (32.1%; 43/134) (p=0.0195). No adverse effects were observed in this study. The results of this study demonstrate the beneficial clinical effects of Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) in stabilizing psychological state in the postpartum period.

Xiong-gui-tiao-xue-yin (Kyuki-chouketsu-in) can be expected to improve the mental health of women in the postpartum period and prevent maternity blues.

The aim of the present investigation was to evaluate the clinical efficacy of Xiong-gui-tiao-xue-yin, a traditional Japanese herbal medicine, in stimulating lactation in the postpartum period. We enrolled 82 women who had a normal delivery in Osaka Medical College Hospital, and randomly assigned them to the following two groups: a group of 41 women who received Xiong-gui-tiao-xue-yin at a dose of 6.0 g/day (Group X), and a group of 41 women who received ergometrine (methylergometrine maleate) at a dose of 0.375 mg/day (Group E). Volume of lactation was determined daily until Day 6 postpartum. Plasma prolactin and oxytocin concentration were measured at Days 1 and 6 postpartum. The results showed that volume of lactation was significantly higher in Group X than in Group E at Days 4 (p = 0.042), 5 (p = 0.038), and 6 (p = 0.046). Significant differences between Groups X and E were noted in plasma prolactin concentration at Days 1 (157.9 ± 78.2 ng/ml and 129.1 ± 64.8 ng/ml; p = 0.037) and 6 (167.5 ± 95.4 ng/ml and 117.1 ± 53.6 ng/ml; p = 0.0042) postpartum. On the other hand, at Day 1, oxytocin concentration was significantly higher in Group E than in Group X (p = 0.0024). No adverse effects were observed in this study. The results of our study demonstrate the beneficial effects of Xiong-gui-tiao-xue-yin on lactation, with increase in prolactin level without increase in oxytocin level in the postpartum period. Therefore, Xiong-gui-tiao-xue-yin can be expected to improve lactation in women in the postpartum period. Further detailed bio-pharmacological studies and clinical trials to investigate the properties of this drug are warranted.

Objective: To analyze the correlation between the vascular endothelial function (characterized by endothelin-1 and nitric oxide) and the renal hemodynamics in patients with hypertensive disorders in pregnancy (HDP) by color Doppler ultrasound.

Method: Depending on the severity of the disease, 76 HDP patients were divided into three groups, namely, pregnancy-induced hypertension (PIH) group ($n=26$), mild preeclampsia (PE) group ($n=28$), and severe PE group ($n=22$). In the meantime, 28 healthy pregnant women were selected as controls. Color Doppler ultrasound was performed to determine the following parameters in the interlobar arteries of the kidney: Resistance index (RI), peak end-diastolic velocity (EDV), pulsatility index (PI), peak systolic velocity (PSV), and S/D ratio. The correlations of these parameters with the serum levels of ET-1 and NO were then analyzed.

Result: (1) In the interlobar arteries of the kidney, RI, S/D, PI were positively significantly correlated to the serum level of ET-1 in HDP patients (All $p<0.001$) and negatively to the serum level of NO (All $p<0.01$). (2) RI, S/D, PI of the mild and severe PE groups were significantly higher than those of the control group (All $p<0.05$). However, EDV of the mild and severe PE groups was significantly lower than that of the control group (All $p<0.05$). (3) The serum level of ET-1 was significantly higher in the HDP patients than in the control group ($p<0.001$). However, the serum level of NO was significantly lower in the former than in the latter ($p<0.001$). As HDP became more severe, there was an elevation in the serum level of ET-1 and a decrease in NO.

Conclusion: Indicators of renal hemodynamics measured by color Doppler ultrasound were correlated to the serum levels of ET-1 and NO characterizing the vascular endothelial function. They were sensitive indicators reflecting hemodynamic changes and renal impairment in HDP patients.