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In this paper, we study the Castelnuovo–Mumford regularity of powers of edge ideals of product of graphs. We find new upper bounds for reg(I(G∗H)s) for various classes of graphs G and H, where G∗H denotes the product of G and H, and I(G∗H) denote the corresponding edge ideal. Using this result, we explicitly compute reg(I(G∗H)s) for several classes of graphs G and H. In particular, we also explicitly compute the regularity of powers of wheel graphs.