Let Xnr,sXnr,s denote the blow-up of ℙn along r general lines and s general points. In this paper, we focus on l-very ample line bundles on Xn0,s and investigate their Seshadri constants with some restrictions on s. Additionally, we compute the nef cone of X3r,0 for r≤6 and study the Seshadri constants of some ample line bundles on it. We also examine the Seshadri constants of some ample line bundles on X4r,0(r≤7) and X5r,0(r≤5).