Different exotic particles have been suggested to be part of the cosmic radiation flux, such as Magnetic Monopoles, Strange Quark Matter, Q-balls in a very wide mass range, from multi-TeV to 1017 GeV and beyond. The SLIM experiment based on a large array of nuclear track detectors at the Chacaltaya Laboratory (Bolivia) reached the highest sensitivity for Intermediate mass MMs, nuclearites and charged Q-balls. After discussing the experimental procedure, the results obtained by the SLIM: experiment are compared with the sensitivity reachable by future searches with large volume neutrino telescopes and space based experiments.