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This study proposes a diagnosis system for liver masses based on the improved radial basis function (RBF) neural networks. In this article, RBF networks are improved by sigmoid function and the growing and pruning algorithm. The proposed improved RBF networks adopt the sigmoid function as their kernel due to its increased flexibility over the Gaussian kernel. Furthermore, the growing and pruning algorithm is used to adjust the network size dynamically according to the neuron's significance. This investigation formulates discriminating among cysts, hepatoma, cavernous hemangioma, and normal tissue as a supervised learning problem. The current work calculates several texture and gray-level features derived from regions of interest as input in the proposed classifier. Receiver operating characteristic (ROC) curves evaluate the diagnosis performance, and demonstrate the proposed method's good performance.