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PIXE ANALYSIS OF THE SERUM OF MICE ACQUIRED RADIO-RESISTIBILITY BY LOW DOSE X-RAYS
Preview AbstractIt is not only important for maintenance and improvement of health, but also indispensable for diagnosis and remedy of diseases to make inquiries into the biological defence mechanisms. Yonezawa et al. came across an induction of yet unknown defence mechanism(s) in mice which acquired radioresistance two weeks after low dose X-irradiation with 0.5 Gy. The 30-day survival rate after midlethal X-irradiation of the mice significantly increased by the pre-irradiation, but contrary to the common knowledge on radiation protection, recovery of the blood cell counts of thrombocytes, leukocytes and erythrocytes were not stimulated by the pre-irradiation. This study was planned to find some keys to elucidate the mechanism for the acquired radioresistance. Metal ions are well known to be important for enzyme activities as well as for metabolisms. Eleven elements, Cl, K, Ca, Cr, Mn, Fe, Ni, Cu, Zn, Se and Br were analysed in mice sera by PIXE.