The gist of the paper is the fundamental uncertain nature of all kinds of uncertainties and consequently a critical epistemic review of historical and recent approaches, computational methods, algorithms. The review follows the development of the notion from the beginnings of thinking, via the Aristotelian and Skeptic view, the medieval nominalism and the influential pioneering metaphors of ancient India and Persia to the birth of modern mathematical disciplinary reasoning. Discussing the models of uncertainty, e.g. the statistical, other physical and psychological background we reach a pragmatic model related estimation perspective, a balanced application orientation for different problem areas. Data mining, game theories and recent advances in approximation algorithms are discussed in this spirit of modest reasoning.