The hypergeometric system E(k,n) and the contiguity operators defined on the space of k×n matrices Zk,n induce the systems and the contiguity operators on the Grassmannian manifold Gk,n:=GLk\Zk,n and on the configuration space X(k,n):=GLk\Zk,n/Hn, where Hn is the group consisting of diagonal matrices of size n. The first purpose of this paper is to give a rigorous treatment of these systems and contiguity operators, the second is to derive a condition that the system E(k,n) is reducible, and the third is to derive the contiguity relations and the contiguous relations satisfied by the solutions of the system on Gk,n or the solutions of the system on X(k,n).