The bending stiffness of footwear impacts running efficiency and lower-limb work redistribution. However, studies integrating both aspects are scarce. This study aimed to examine the impact of footwear stiffness on lower-limb biomechanics, joint work, and overall metabolic efficiency. This study was performed on 12 male recreational runners to complete an experimental protocol while wearing two different running shoes with varying degrees of longitudinal bending stiffness. Paired-sample t tests were applied in this research. The stiffer footwear decreased the range of motion (ROM), angular velocity, negative and positive work of the metatarsophalangeal (MTP) joint, and ROM of the ankle joint. The running economy significantly improved with the stiffer footwear. However, no significant difference was observed in the joint work of other lower limbs. Shoes with increased bending stiffness significantly reduced the MTP joint ROM and angular velocity, thereby reducing negative power and work at the MTP joint and improving running economy for runners. This study provided relevant information for shoe designers, developers, and scientists conducting research on footwear midsole structures and designs.