In this paper, we use a biorthogonal approach to the analysis of the infinite dimensional fractional Poisson measure πβσ, 0<β≤1, on the dual of Schwartz test function space 𝒟′. The Hilbert space L2(πβσ) of complex-valued functions is described in terms of a system of generalized Appell polynomials ℙσ,β,α associated to the measure πβσ. The kernels Cσ,βn(⋅), n∈ℕ0, of the monomials may be expressed in terms of the Stirling operators of the first and second kind as well as the falling factorials in infinite dimensions. Associated to the system ℙσ,β,α, there is a generalized dual Appell system ℚσ,β,α that is biorthogonal to ℙσ,β,α. The test and generalized function spaces associated to the measure πβσ are completely characterized using an integral transform as entire functions.