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The $\epsilon$-insensitive-Least Squares Support Vector Regression ($\epsilon$-LSSVR) optimization problem with $\epsilon$-insensitive quadratic loss function is a non-smooth, piecewise quadratic complex problem. Therefore, the optimal solution of $\epsilon$-LSSVR takes longer than Classic LSSVR. Additionally, due to its unbounded influence function, $\epsilon$-LSSVR, like classical LSSVR, shows poor generalization ability in the presence of outliers. To overcome the above-mentioned drawbacks, this paper presents an $\epsilon$-insensitive Weighted Least Squares Support Vector Regression ($\epsilon$-WLSSVR) with equality constraints to increase robustness against outliers. To reduce the computational complexity and time, the optimization problem of $\epsilon$-WLSSVR is solved by the Sequential Minimal Optimization (SMO) algorithm. Extensive simulations have shown that the presented $\epsilon$-WLSSVR model combined with the SMO algorithm is more effective and efficient than LSSVR and its known sparse variants.

The nucleotide-binding domain leucine-rich repeat-containing (NLR) proteins plays significant role in the intestinal tissue repair and innate immunity. It recently added to the members of innate immunity effectors molecules. It also plays an essential role in intestinal microbiota and recently emerged as a crucial hit for developing ulcerative colitis (UC) and colitis-associated cancer (CAC). A machine learning-based approach for predicting NLR proteins has been developed. In this study, we present a comparison of three supervised machine learning algorithms. Using ProtR and POSSUM Packages, the features are extracted for the dataset used in this work. The models are trained with the input compositional features generated using dipeptide composition, amino acid composition, etc., as well as Position Specific Scoring Matrix (PSSM) based compositions. The dataset consists of 390 proteins for the negative and positive datasets. The five-fold cross-validation (CV) is used to optimize Sequential Minimal Optimization (SMO) library of Support Vector Machine (LIBSVM) and Random Forest (RF) parameters, and the best model was selected. The proposed work performs rationally well with an accuracy of 90.91% and 93.94% for RF as the best classifier for the Amino Acid Composition (AAC) and PSE_PSSM-based model. We believe that this method is a reliable, rapid and useful prediction method for NLR Protein.

The coronavirus or COVID-19 infectious virus is the deadliest and potentially dangerous disease for humans. Radiologists frequently employ medical imaging tools to visualize complex internal structures as well as the functioning of the body. With precise diagnosis, it is possible to identify the infectious COVID-19 virus earlier, especially in an individual having no visible symptoms. For the diagnosis and early detection of the infectious COVID-19 virus, chest X-rays (CXRs) have been utilized which are available at https://www.kaggle.com/datasets/tawsifurrahman/covid19-radiography-database. Applying the gray-level co-occurrence matrix (GLCM) and gray-level run length matrix (GLRLM) feature extraction techniques, the features of the four classes (normal, lung opacity, viral pneumonia, and COVID-19) have been extracted and then classified by utilizing a machine learning (ML) classifier. Six distinct ML classifiers SMO (Sequential Minimal Optimization), Random Tree, MLP (Multi-Layer Perceptron), Linear SVM, Ensemble Classifier (Boosted Tree), and Bayes Net (Bayesian Network) with respective accuracy of 98.85%, 93.19%, 93.35%, 91.5%, 96.4%, and 96.454% are utilized to classify. The classifiers successfully distinguish between normal individuals, viral pneumonia-affected persons, lung opacity individuals, and COVID-19 virus-infected individuals who were considered for the study. These advanced technologies for coronavirus identification may be helpful in areas where access to skilled medical professionals and modern facilities is limited. Hence, as per the analysis, the study may be helpful in disease detection and classification. To classify the virus, radiologists’ second opinion can be quick and accurate in this urgent scenario.