Given an integral domain DD with quotient field KK, the study of the ring of integer-valued polynomials Int(D)={f∈K[X]|f(a)∈Dfor alla∈D}Int(D)={f∈K[X]|f(a)∈Dfor alla∈D} has attracted a lot of attention over the past decades. Recently, Werner has extended this study to the situation of skew polynomials. To be more precise, if σσ is an automorphism of KK, one may consider the set Int(D,σ)={f∈K[X,σ]|f(a)∈Dfor alla∈D}Int(D,σ)={f∈K[X,σ]|f(a)∈Dfor alla∈D}, where K[X,σ]K[X,σ] is the skew polynomial ring and f(a)f(a) is a “suitable” evaluation of ff at aa. For example, he gave sufficient conditions for Int(D,σ)Int(D,σ) to be a ring and study some of its properties. In this paper, we extend the study to the situation of the skew polynomial ring K[X,σ,δ]K[X,σ,δ] with a suitable evaluation, where δδ is a σσ-derivation. Moreover we prove, for example, that if σσ is of finite order and DD is a Dedekind domain with finite residue fields such that Int(D,σ)Int(D,σ) is a ring, then Int(D,σ)Int(D,σ) is non-Noetherian.