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Worldwide, epidemics continue to be a concern on public health. Even with the technological advances, there are still barriers present in predicting the outbreaks. We propose a new methodology known as FREEDOM (Effective Surveillance and Investigation of Water-borne Diseases from data-centric networking using Machine Learning) to perform effective surveillance and investigation of water-borne diseases from social media with next-generation data. In the proposed model, we collected the data from the Twitter media, preprocessed the tweet content, performed hierarchical spectral clustering, and generated the frequent word set from each cluster through the apriori algorithm. At last, the inferences are extracted from the frequent word set through human intervention. From the experimental results, the support and confidence value of the outcome derived from the Apriori algorithm has exhibited the different water-borne diseases that are not listed in the WHO (World Health Organization), and the surveillance of those diseases with percentage ranking and has been achieved using the data-centric networking. They get aligned with precise results portraying real statistics. This type of analysis will empower doctors and health organizations (Government sector) to keep track of the water-borne diseases, their symptoms for early detection, and safe recovery thereby sufficiently reducing the death tolls.