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In the light of existing physical theories, it is shown that representation in terms of functional interactions and formalism (S-Propagators) should satisfy three physical and six biological constraints. Consequences are summarized for neurohormonal field, developmental phase, aging phase, functional hierarchy, Principle of Auto-Associative stability (PAAS), self-organization and neural selection, Darwinian evolution, and the intelligence of movement. Abstraction and complexity of the proposed theories are discussed relatively to their advantages for integrative neuroscience.