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SINGAPORE – Asia Pacific Medical Technology Association (APACMed) Announces Partnership with Duke-NUS Medical School’s Centre of Regulatory Excellence (CoRE), Pledging Joint Commitment to Promote Regulatory Convergence and Capacity Building Across the Region.

SINGAPORE – Guardian Partners with MyDoc to Address Singapore’s Population Health Needs through Integrating Technology and Self-Care.

SINGAPORE & UNITED STATES – CellMax Life’s Precision, Non-Invasive Cancer Testing Now Available throughout Southeast Asia through Asia Genomics.

UNITED STATES – 3-D Printed Models Could Improve Patient Outcomes in Heart Valve Replacements.

UNITED STATES – Promising Target to Protect Bone in Patients with Diabetes.

UNITED STATES – New Antibody Appears to Re-Activate Immune System in Cancer Therapy.

UNITED STATES – Combo Immunotherapy May Herald New Standard of Care for Kidney Cancer.

JAPAN – Chugai’s Bispecific Antibody “Emicizumab” Global Phase III Data in Patients with Haemophilia A with Inhibitors Published in The New England Journal of Medicine Online.

RUSSIA & INDIA – BIOCAD’s Rituximab Biosimilar to Receive Market Authorization Soon in India.

The incidence and prevalence of nonalcoholic fatty liver disease (NAFLD) have been increasing to epidemic proportions around the world. NAFLD, a chronic liver disease that affects the nondrinkers, is mainly associated with steatohepatitis and cirrhosis. The progression of NAFLD associated with obesity increases the risk of liver cancer, a disease with poor outcomes and limited therapeutic options. In order to investigate the underlying cellular dynamics leading to NAFLD progression towards cancer on the onset of obesity, we have integrated human hepatocyte pathway with hypoxia-inducible factor1-$\alpha$ (HIF1-$\alpha$) signaling pathway using state space model based on classical control theory. Modified Michaelis–Menten equation and mass action law have been used to define flux vectors of the proposed model. We have incorporated feedback inhibition/activation and allosteric effects into the simulink-based model. The values of kinetic constants have been taken from the literature. It is found that on the onset of obesity, HIF1-$\alpha$-induced proteins stabilize approximately 62 times that in the case of a normal cell. Consequently, the HIF1-$\alpha$-induced proteins enhance the enzymatic activities of hexokinase (HK), phosphofructo kinase (PFK), lactate dehydrogenase (LDH), and pyruvate dehydrogenase (PDH), which induce Warburg effect promoting an environment suitable for cancer cells.

Yeast S. cerevisiae sometimes inhabit in the environment, acidity of which is connected with significant L-malate concentrations. For example, such situation develops during manufacture of dry grape wines. Low-active transporter-receptor of inorganic phosphate with pH optimum in alkaline area was characterized recently in plasma membrane of this yeast. Earlier we have found out low-active (13.8 ± 0.4 nmol/min/1 mg of dry weight) plasma membrane dicarboxylate transporter sensitive to 2-undecyl malonate. It has been difficult to study because of its low activity and special properties. This S. cerevisiae transporter has alkaline pH-optimum and transports succinate more effectively, than citrate. After 15-18h of aerobic preincubation at 0°C of yeast cells, external Land D-malate stimulates respiration and 2-undecyl malonate inhibits oxidation of both substrates. However the malate oxidation becomes negligible after 24-26h of such preincubation. These stereoisomers competitively inhibits the succinate oxidation and transplasmalemmal transport of this dicarboxylate into cells limits respiration at that. Change of the incubation medium pH value from 5.5 to 6.5 causes growth of the ratio value of IC₅₀ (one of the parameters of inhibition) of D-malate and IC₅₀ of L-malate from 1.0 to 6.4. At the same time succinate dianion affinity varies a little bit. Such selective regulation of transplasmalemmal dicarboxylate transporter affinity may indicate that this carrier is a malate receptor and a probable sensor of extracellular pH.